Evolving Treatment Landscape for Advanced Esophageal and Gastroesophageal Junction Adenocarcinoma

被引：1
|
作者：
Wheless, Margaret C. [1 ]
Comer, Margaret [2 ]
Gibson, Michael K. [1 ,3 ]
机构：
[1] Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Med Sch, Nashville, TN USA
[3] Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Med Ctr, 2220 Pierce Ave,777 Preston Res Bldg, Nashville, TN 37232 USA
来源：
CURRENT ONCOLOGY REPORTS | 2024年 / 26卷 / 11期
关键词：
Esophageal Adenocarcinoma; Gastroesophageal Junction Adenocarcinoma; Claudin18.2; FGFR; HER-2; PD-L1; Therapy; ADVANCED GASTRIC-CANCER; PEMBROLIZUMAB PLUS CHEMOTHERAPY; SQUAMOUS-CELL CARCINOMA; RANDOMIZED PHASE-III; TRASTUZUMAB EMTANSINE; OPEN-LABEL; PRELIMINARY EFFICACY; SOLID TUMORS; DOUBLE-BLIND; CISPLATIN;
D O I：
10.1007/s11912-024-01607-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose of ReviewThis review highlights advances and recent changes in the treatment paradigm for advanced esophageal adenocarcinoma (EAC) and gastroesophageal junction adenocarcinoma (GEJAC).Recent FindingsChemotherapy remains the backbone of treatment for advanced EAC/GEJAC. New targets/agents include immunotherapy, HER-2, claudin18.2, and FGFR2b, with various mechanisms (CAR-T, bispecific mAB, ADCs) altering the treatment landscape against these targets.SummaryThe approaches to these targets may act together, in sequence, and even synergistically to improve outcomes. Herein, we review the state of the field, including highlighting ongoing clinical trials and additional emerging agents and approaches.
引用
收藏
页码：1469 / 1488
页数：20
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