Crosslinking substrate regulates frictional properties of tissue-engineered cartilage and chondrocyte response to loading

被引：0
|
作者：
Christoph Meinert [1 ]
Angus Weekes [2 ]
Chun-Wei Chang [1 ]
Karsten Schrobback [3 ]
Amy Gelmi [4 ]
Molly M. Stevens [1 ]
Dietmar W. Hutmacher [3 ]
Travis J. Klein [5 ]
机构：
[1] Queensland University of Technology (QUT),Centre for Biomedical Technologies
[2] Gelomics Pty Ltd.,Max Planck Queensland Centre (MPQC) for the Materials Science of Extracellular Matrices
[3] Queensland University of Technology (QUT),School of Mechanical, Medical and Process Engineering, Faculty of Engineering
[4] Queensland University of Technology (QUT),Centre for Genomics and Personalised Health, School of Biomedical Sciences
[5] Queensland University of Technology (QUT),Department of Materials
[6] Imperial College London,Department of Bioengineering
[7] Imperial College London,Institute of Biomedical Engineering
[8] Imperial College London,undefined
来源：
Communications Materials | / 6卷 / 1期
关键词：
D O I：
10.1038/s43246-025-00781-8
中图分类号：
学科分类号：
摘要：
Hydrogels are frequently used in regenerative medicine due to their hydrated, tissue-compatible nature, and tuneable mechanics. While many strategies enable bulk mechanical modulation, little attention is given to tuning surface tribology, and its impact on cellular behavior under mechanical stimuli. Here, we demonstrate that photocrosslinking hydrogels on hydrophobic substrates leads to significant, long-lasting reductions in surface friction, ideal for cartilage tissue regeneration. Gelatin methacryloyl and hyaluronic acid methacrylate hydrogels photocrosslinked on polytetrafluoroethylene possess more hydrated, lubricious surfaces, with lower friction coefficients and crosslinking densities than those crosslinked on glass. This facilitated self-lubrication via water exudation, limiting shear during biaxial stimulation. When subject to intermittent biaxial loading mimicking joint movement, low-friction chondrocyte-laden neo-tissues formed superior hyaline cartilage, confirming the benefits of reduced friction on tissue development. Finally, in situ photocrosslinking enabled precise hydrogel formation in a full-thickness cartilage defect, highlighting the clinical potential and emphasizing the importance of crosslinking substrate in regenerative medicine.
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