Associations between past infectious mononucleosis diagnosis and 47 inflammatory and vascular stress biomarkers

被引:0
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作者
Kristjansson, Ragnar P. [1 ]
Dietz, Jojo Biel-Nielsen [1 ]
Davidsson, Olafur B. [1 ]
Kjerulff, Bertram [2 ,3 ,4 ]
Rostgaard, Klaus [1 ,5 ]
Dowsett, Joseph [6 ]
Soegaard, Signe Holst [1 ,7 ]
Rotbain, Emelie Curovic [1 ,8 ]
Schwinn, Michael [6 ]
Burgdorf, Kristoffer Solvsten [9 ,10 ]
Bay, Jakob Thaning [11 ]
Mikkelsen, Christina [6 ,12 ]
Ullum, Henrik [10 ]
Brunak, Soren [9 ]
Sorensen, Erik [6 ]
Jensen, Bitten Aagaard [13 ]
Bruun, Mie Topholm [14 ]
Nyegaard, Mette [10 ,15 ]
Ostrowski, Sisse Rye [6 ,16 ]
Pedersen, Ole Birger [11 ,16 ]
Erikstrup, Christian [2 ,3 ,4 ]
Hansen, Thomas Folkmann [9 ,17 ]
Hjalgrim, Henrik [1 ,5 ,16 ]
机构
[1] Danish Canc Soc, Res Ctr, Copenhagen, Denmark
[2] Aarhus Univ Hosp, Dept Clin Immunol, Aarhus, Denmark
[3] Aarhus Univ, Dept Clin Med, Aarhus, Denmark
[4] Aarhus Univ, BERTHA Big Data Ctr Environm & Hlth, Aarhus, Denmark
[5] Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark
[6] Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark
[7] Statens Serum Inst, Dept Congenital Disorders, Copenhagen, Denmark
[8] Copenhagen Univ Hosp, Rigshosp, Dept Hematol, Copenhagen, Denmark
[9] Univ Copenhagen, Novo Nord Fdn, Fac Hlth & Med Sci, Translat Dis Syst Biol,Ctr Prot Res, Copenhagen, Denmark
[10] Statens Serum Inst, Copenhagen, Denmark
[11] Zealand Univ Hosp, Dept Clin Immunol, Koge, Denmark
[12] Univ Copenhagen, Novo Nord Fdn, Fac Hlth & Med Sci, Ctr Basic Metab Res, Copenhagen, Denmark
[13] Aalborg Univ Hosp, Dept Clin Immunol, Aalborg, Denmark
[14] Odense Univ Hosp, Dept Clin Immunol, Odense, Denmark
[15] Aalborg Univ, Dept Hlth Sci & Technol, Aalborg, Denmark
[16] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark
[17] Copenhagen Univ Hosp, Rigshosp Glostrup, Translat Res Ctr, Neurogenom Grp, Glostrup, Denmark
来源
SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期
关键词
EPSTEIN-BARR-VIRUS; C-REACTIVE PROTEIN; BIRTH-ORDER; RISK-FACTOR; EXPOSURE; CARE; RESPONSES; DISEASE; GENDER; SYSTEM;
D O I
10.1038/s41598-025-95276-4
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Infectious mononucleosis (IM), predominantly caused by primary Epstein-Barr virus (EBV) infection, is a common disease in adolescents and young adults. EBV infection is nearly ubiquitous globally. Although primary EBV infection is asymptomatic in most individuals, IM manifests in a subset infected during adolescence or young adulthood. IM occurrence is linked to sibship structure, and is associated with increased risk of multiple sclerosis, other autoimmune diseases, and cancer later in life. We analyzed 47 biomarkers in 5,526 Danish individuals aged 18-60 years, of whom 604 had a history of IM, examining their associations with IM history up to 48 years after IM diagnosis. No significant long-term associations were observed after adjusting for multiple comparisons. When restricting the analysis to individuals measured within 10 years post-IM diagnosis, a statistically significant increase in CRP levels was observed in females. This association was not driven by oral contraceptive use. No significant associations between sibship structure and biomarker levels were detected. In conclusion, our study shows that while IM may lead to a transient increase in CRP levels in females, it does not result in long-term alterations in plasma biomarkers related to immune function, suggesting other mechanisms may be responsible for the long-term health impacts associated with IM.
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页数:10
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