Avascular necrosis or rapid destruction of the hip following hip intra-articular corticosteroid injections: a systematic review

PurposeThis study aimed to systematically review the literature to identify the incidence of avascular necrosis (AVN) following hip intra-articular corticosteroid injections (IACSIs) as well as to elucidate risk factors that may predispose patients to AVN following IACSI.MethodsThe MEDLINE, Embase, PubMed, and Web of Science databases were systematically searched through inception to July 21, 2024, in accordance with the PRISMA statement with data extracted for descriptive analysis. The inclusion criteria were hip IACSI and AVN of the femoral head. AVN identified solely prior to IACSI, animal studies, in vitro studies, and studies on paediatric populations were excluded.ResultsA total of 3,652 studies were identified and screened resulting in a total of 14 studies that met the inclusion criteria. Seven were case reports, four were retrospective case-series, and three were retrospective cohort studies. The incidence of femoral head AVN following IACSI ranged from 0.6 to 20.4%. Kelly et al. reported that patient-related factors associated with increased rate of AVN included elevated BMI (p = 0.025), history of cancer therapy (p = 0.012), low serum Vitamin D (p = 0.030), and multiple injections (p = 0.004).ConclusionIn the present literature, the incidence of AVN after hip IACSI ranges from 0.6 to 20.4% with mean follow-up times ranging from 5.4 to 25.3 months. Further randomized controlled trials are necessary to elucidate if there is a causative relationship between hip IACSI and AVN.