Artesunate: attenuating TLR4/MD2 signaling to alleviate cardiac fibrosis

被引:0
|
作者
Koch, Lars [1 ]
Hoeft, Konrad [1 ,2 ]
Kramann, Rafael [1 ,2 ]
机构
[1] Rhein Westfal TH Aachen, Med Fac, Dept Med 2, Aachen, Germany
[2] Erasmus MC, Dept Internal Med Nephrol & Transplantat, Rotterdam, Netherlands
基金
欧洲研究理事会;
关键词
D O I
10.1038/s41392-025-02131-z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Dissecting the species-specific recognition of Neoseptin 3 by TLR4/MD2 via molecular dynamics simulations
    Wu, Siru
    Zhang, Cong
    Wang, Yibo
    Li, Penghui
    Du, Xiubo
    Wang, Xiaohui
    PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2023, 25 (18) : 13012 - 13018
  • [42] Computationally Designed Bispecific MD2/CD14 Binding Peptides Show TLR4 Agonist Activity
    Michaeli, Amit
    Mezan, Shaul
    Kuehbacher, Andreas
    Finkelmeier, Doris
    Elias, Maayan
    Zatsepin, Maria
    Reed, Steven G.
    Duthie, Malcolm S.
    Rupp, Steffen
    Lerner, Immanuel
    Burger-Kentischer, Anke
    JOURNAL OF IMMUNOLOGY, 2018, 201 (11): : 3383 - 3391
  • [43] Sevoflurane inhibits cardiac function in pulmonary fibrosis mice through the TLR4 signaling pathway
    Cao, Yanan
    He, Zhenghua
    Zhu, Maoen
    Gao, Xiaowei
    Yang, Yue
    Zhang, Junjie
    Pan, Yundan
    Guo, Qulian
    Peng, Yonggang
    Wang, E.
    PULMONARY CIRCULATION, 2018, 8 (04)
  • [44] TLR4/MD2/NF-κB信号通路与疾病的研究进展
    宋瑜婷
    彭彬
    王莹
    张雪
    曹帆帆
    张登海
    免疫学杂志, 2020, (07) : 633 - 638
  • [45] Selective targeting of the TLR4 co-receptor, MD2, prevents colon cancer growth and lung metastasis
    Rajamanickam, Vinothkumar
    Yan, Tao
    Xu, Shanmei
    Hui, Junguo
    Xu, Xiaohong
    Ren, Luqing
    Liu, Zhoudi
    Liang, Guang
    Wang, Ouchen
    Wang, Yi
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2020, 16 (08): : 1288 - 1302
  • [46] TLR4 and MD2 variation among horses with differential TNFα baseline concentrations and response to intravenous lipopolysaccharide infusion
    Abhijit Mukhopadhyay
    Shawna R. Cook
    Phillip SanMiguel
    Kari J. Ekenstedt
    Sandra D. Taylor
    Scientific Reports, 13 (1)
  • [47] Pinostrobin ameliorates lipopolysaccharide (LPS)-induced inflammation and endotoxemia by inhibiting LPS binding to the TLR4/MD2 complex
    Athapaththu, Athapaththu Mudiyanselage Gihan Kavinda
    Lee, Kyeong Tae
    Kavinda, Mirissa Hewage Dumindu
    Lee, Seunghun
    Kang, Sanghyuck
    Lee, Mi-Hwa
    Kang, Chang -Hee
    Choi, Yung Hyun
    Kim, Gi-Young
    BIOMEDICINE & PHARMACOTHERAPY, 2022, 156
  • [48] Pentamidine Alleviates Inflammation and Lipopolysaccharide-Induced Sepsis by Inhibiting TLR4 Activation via Targeting MD2
    Wu, Siru
    Lin, Cong
    Zhang, Tianshu
    Zhang, Bo
    Jin, Yushan
    Wang, Hongshuang
    Li, Hongyuan
    Wang, Yibo
    Wang, Xiaohui
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [49] TLR4 and MD2 variation among horses with differential TNFα baseline concentrations and response to intravenous lipopolysaccharide infusion
    Mukhopadhyay, Abhijit
    Cook, Shawna R.
    SanMiguel, Phillip
    Ekenstedt, Kari J.
    Taylor, Sandra D.
    SCIENTIFIC REPORTS, 2023, 13 (01):
  • [50] Lipoteichoic Acid Inhibits Lipopolysaccharide-Induced TLR4 Signaling by Forming an Inactive TLR4/MD-2 Complex Dimer
    Watanabe, Sachiko
    Zenke, Kosuke
    Muroi, Masashi
    JOURNAL OF IMMUNOLOGY, 2023, 210 (09): : 1386 - 1395