Artesunate: attenuating TLR4/MD2 signaling to alleviate cardiac fibrosis

被引:0
|
作者
Koch, Lars [1 ]
Hoeft, Konrad [1 ,2 ]
Kramann, Rafael [1 ,2 ]
机构
[1] Rhein Westfal TH Aachen, Med Fac, Dept Med 2, Aachen, Germany
[2] Erasmus MC, Dept Internal Med Nephrol & Transplantat, Rotterdam, Netherlands
基金
欧洲研究理事会;
关键词
D O I
10.1038/s41392-025-02131-z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页数:2
相关论文
共 50 条
  • [1] MD2 Inhibits Choroidal Neovascularization via Antagonizing TLR4/MD2 Mediated Signaling Pathway
    Wu, Qi
    Chen, Zhang
    Wu, Chenxin
    Zhang, Lingxi
    Wu, Yuyang
    Liu, Xiyuan
    Wang, Yi
    Zhang, Zongduan
    CURRENT EYE RESEARCH, 2023, 48 (05) : 474 - 484
  • [2] Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling
    Li, Hongyuan
    Peng, Yinghua
    Lin, Cong
    Zhang, Xiaozheng
    Zhang, Tianshu
    Wang, Yibo
    Li, Yuanpeng
    Wu, Siru
    Wang, Hongshuang
    Hutchinson, Mark R.
    Watkins, Linda R.
    Wang, Xiaohui
    INNOVATION, 2021, 2 (02):
  • [3] Targeting the TLR4–MD2 axis in systemic sclerosis
    Steven O’Reilly
    Jacob M. van Laar
    Nature Reviews Rheumatology, 2018, 14 : 564 - 566
  • [4] HMGB1 BINDS TO MD2 IN THE TLR4/MD2 COMPLEX TO ELICIT INFLAMMATORY RESPONSES
    Yang, H.
    Ochani, M.
    Rosas, M.
    Li, J.
    Lu, B.
    Chavan, S.
    Tracey, K. J.
    SHOCK, 2011, 35 : 33 - 33
  • [5] Soluble MD2 increases TLR4 levels on the epithelial cell surface
    Lauer, Sabine
    Kunde, Yuliya A.
    Apodaca, Theresa A.
    Goldstein, Byron
    Hong-Geller, Elizabeth
    CELLULAR IMMUNOLOGY, 2009, 255 (1-2) : 8 - 16
  • [6] Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2
    Koo, Jung Eun
    Park, Zee-Yong
    Kim, Nam Doo
    Lee, Joo Young
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 434 (03) : 600 - 605
  • [7] Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2
    Raghavan, B.
    Martin, S. F.
    Esser, P. R.
    Goebeler, M.
    Schmidt, M.
    EXPERIMENTAL DERMATOLOGY, 2013, 22 (03) : E4 - E4
  • [8] Selective targeting of MD2 attenuates intestinal inflammation and prevents neonatal necrotizing enterocolitis by suppressing TLR4 signaling
    Huang, Dabin
    Wang, Ping
    Chen, Juncao
    Li, Yanbin
    Zhu, Mingwei
    Tang, Yaping
    Zhou, Wei
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [9] Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2
    Raghavan, Badrinarayanan
    Martin, Stefan F.
    Esser, Philipp R.
    Goebeler, Matthias
    Schmidt, Marc
    EMBO REPORTS, 2012, 13 (12) : 1109 - 1115
  • [10] Desialylation of TLR4/MD2/CD14 enhances the response to LPS
    Feng, Chiguang
    Whitford, Melissa
    Zhang, Lei
    Rallabhandi, Prasad
    Vogel, Stefanie N.
    Stamatos, Nicholas M.
    JOURNAL OF IMMUNOLOGY, 2009, 182