Effectiveness of tacrolimus therapy in refractory ulcerative colitis compared to infliximab with propensity score matching

被引：0

作者：

Yoshihara, Takeo ^{[1
]}

Amano, Takahiro ^{[1
]}

Shinzaki, Shinichiro ^{[1
,2
]}

Tsujii, Yuri ^{[1
]}

Asakura, Akiko ^{[1
]}

Tashiro, Taku ^{[1
]}

Tani, Mizuki ^{[1
]}

Otake-Kasamoto, Yuriko ^{[1
]}

Yamada, Takuya ^{[3
]}

Sakakibara, Yuko ^{[4
]}

Osugi, Naoto ^{[5
]}

Ishii, Shuji ^{[6
]}

Egawa, Satoshi ^{[7
]}

Araki, Manabu ^{[8
]}

Arimoto, Yuki ^{[9
]}

Nakahara, Masanori ^{[10
]}

Murayama, Yoko ^{[11
]}

Kobayashi, Ichizo ^{[12
]}

Kinoshita, Kazuo ^{[13
]}

Ogawa, Hiroyuki ^{[14
]}

Hiyama, Satoshi ^{[15
]}

Shibukawa, Narihiro ^{[16
]}

Komori, Masato ^{[17
]}

Okuda, Yorihide ^{[18
]}

Kizu, Takashi ^{[19
]}

Kitamura, Tetsuhisa ^{[20
]}

Kato, Minoru ^{[1
]}

Tsujii, Yoshiki ^{[1
]}

Inoue, Takahiro ^{[1
]}

Iijima, Hideki ^{[7
]}

Hayashi, Yoshito ^{[1
]}

Takehara, Tetsuo ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, 2-2 K1 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Hyogo Med Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Nishinomiya, Japan

[3] Osaka Rosai Hosp, Dept Gastroenterol & Hepatol, Sakai, Japan

[4] Natl Hosp Org, Osaka Natl Hosp, Osaka, Japan

[5] Toyonaka City Hosp, DEPT RADIOL, TOYONAKA, Japan

[6] Osaka Gen Med Ctr, Dept Gastroenterol, Osaka, Japan

[7] Osaka Police Hosp, Dept Gastroenterol, Osaka, Japan

[8] Natl Hosp Org, Dept Pathol, Kawachi Nagano, Japan

[9] Kansai Rosai Hosp, Dept Gastroenterol Surg, Amagasaki, Japan

[10] Ikeda City Hosp, Dept Gastroenterol, Ikeda, Japan

[11] Itami City Hosp, Dept Gastroenterol & Hepatol, Itami, Japan

[12] Higashiosaka City Med Ctr, Dept Gastroenterol, Higashiosaka, Japan

[13] Otemae Hosp, Dept Gastroenterol, Osaka, Japan

[14] Nishinomiya Municipal Cent Hosp, Dept Gastroenterol, Nishinomiya, Japan

[15] Japan Community Healthcare Org Osaka Hosp, Dept Gastroenterol, Osaka, Japan

[16] Daini Osaka Police Hosp, Dept Gastroenterol, Osaka, Japan

[17] Hyogo Prefectural Nishinomiya Hosp, Dept Gastroenterol, Nishinomiya, Japan

[18] Saiseikai Senri Hosp, Dept Gastroenterol, Suita, Japan

[19] Yao Municipal Hosp, Dept Gastroenterol, Yao, Japan

[20] Osaka Univ, Grad Sch Med, Dept Social & Environm Med, Environm Med & Populat Sci, Suita, Osaka, Japan

来源：

SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期

关键词：

Propensity score matching analysis; Calcineurin inhibitors; Ulcerative colitis; CYCLOSPORINE; EFFICACY; SAFETY;

D O I：

10.1038/s41598-024-77365-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There is insufficient evidence comparing the outcomes of tacrolimus-based remission induction therapy with infliximab in refractory ulcerative colitis (UC) and evidence regarding optimal strategies after tacrolimus-based remission induction therapy. We conducted a multi-institutional retrospective study of patients with UC treated with tacrolimus or infliximab between January 2010 and March 2019. The proportion of clinical remission at week 8 and cumulative colectomy-free rate were examined using propensity score matching analysis. The predictors for colectomy after tacrolimus induction were also investigated. Ninety patients in the tacrolimus group and 151 in the infliximab group were enrolled. The proportion of patients in clinical remission at week 8 was 65.2% in the matched tacrolimus group and 37.3% in the matched infliximab group (P = 0.0016), and the long-term colectomy-free rate was lower in the matched tacrolimus group than in the matched infliximab group (P = 0.0003). After clinical remission with tacrolimus, a serum albumin level of <= 3.5 g/dL at week 8 was extracted as a factor predicting colectomy (area under the curve: 0.94). Tacrolimus showed a higher remission induction effect for UC compared to infliximab. However, a high rate of colectomy after transition to maintenance treatment was found to be a concern for tacrolimus therapy.

引用

页数：12

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