Multiple allosteric mechanisms suppress PRC2 activity at active genes

被引：0

作者：

Worden, Evan J. ^{[1
]}

机构：

[1] Van Andel Inst, Dept Struct Biol, Grand Rapids, MI 49503 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2025年 / 32卷 / 02期

关键词：

METHYLATION;

D O I：

10.1038/s41594-025-01487-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PRC2-dependent H3K27 methylation must be excluded from active genes to support appropriate transcriptional programs. Structures of PRC2 bound to nucleosome substrates containing histone modifications associated with active transcription explain how PRC2 is inhibited at active genes.

引用

页码：215 / 216

页数：2

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