Gut GABA keeps ILC3s in check

被引：0
|
作者：
Hepworth, Matthew R. [1 ,2 ]
机构：
[1] Univ Manchester, Fac Biol Med & Hlth, Manchester Acad Hlth Sci Ctr, Sch Biol Sci, Manchester, England
[2] Univ Manchester, Lydia Becker Inst Immunol & Inflammat, Manchester, England
来源：
NATURE IMMUNOLOGY | 2025年 / 26卷 / 03期
基金：
英国惠康基金;
关键词：
INNATE LYMPHOID-CELLS; IMMUNE;
D O I：
10.1038/s41590-025-02082-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
GABA production by enteric neurons suppresses ILC3 activation to prevent inflammation and maintain gut homeostasis.
引用
收藏
页码：335 / 336
页数：2
相关论文
共 50 条
  • [21] The crosstalk between ILC3s and adaptive immunity in diseases
    Wang, Wenyan
    Li, Na
    Guo, Xiaohuan
    FEBS JOURNAL, 2024, 291 (18) : 3965 - 3977
  • [22] ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut
    Lyu, Mengze
    Suzuki, Hiroaki
    Kang, Lan
    Gaspal, Fabrina
    Zhou, Wenqing
    Goc, Jeremy
    Zhou, Lei
    Zhou, Jordan
    Zhang, Wen
    Shen, Zeli
    Fox, James G.
    Sockolow, Robbyn E.
    Laufer, Terri M.
    Fan, Yong
    Eberl, Gerard
    Withers, David R.
    Sonnenberg, Gregory F.
    NATURE, 2022, 610 (7933) : 744 - +
  • [23] Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis
    Cristina Godinho-Silva
    Rita G. Domingues
    Miguel Rendas
    Bruno Raposo
    Hélder Ribeiro
    Joaquim Alves da Silva
    Ana Vieira
    Rui M. Costa
    Nuno L. Barbosa-Morais
    Tânia Carvalho
    Henrique Veiga-Fernandes
    Nature, 2019, 574 : 254 - 258
  • [24] Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis
    Godinho-Silva, Cristina
    Domingues, Rita G.
    Rendas, Miguel
    Raposo, Bruno
    Ribeiro, Helder
    da Silva, Joaquim Alves
    Vieira, Ana
    Costa, Rui M.
    Barbosa-Morais, Nuno L.
    Carvalho, Tania
    Veiga-Fernandes, Henrique
    NATURE, 2019, 574 (7777) : 254 - +
  • [25] The herbal medicine 'Indigo naturalis' altered gut microbiota to accumulate IL-22+ ILC3s
    Yoshimatsu, Yusuke
    Teratani, Toshiaki
    Sujino, Tomohisa
    Mikami, Yohei
    Ichikawa, Masataka
    Hagihara, Yuya
    Takada, Yoshiaki
    Tanemoto, Shun
    Umeda, Satoko
    Nomura, Ena
    Ono, Keiko
    Sugimoto, Shinya
    Nanki, Kosaku
    Naganuma, Makoto
    Kanai, Takanori
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
  • [26] ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice
    Wang, Wenyan
    Li, Na
    Xu, Hongkai
    Wei, Siting
    Li, Yiping
    Ou, Jiayao
    Hao, Jiacheng
    Zhang, Jing
    Dong, Liyou
    Qiu, Ying
    Hu, Xiaoyu
    Fu, Yang-Xin
    Guo, Xiaohuan
    NATURE MICROBIOLOGY, 2025, 10 (03): : 654 - 666
  • [27] Crosstalk between ILC3s and Microbiota: Implications for Colon Cancer Development and Treatment with Immune Check Point Inhibitors
    Drommi, Fabiana
    Calabro, Alessia
    Vento, Grazia
    Pezzino, Gaetana
    Cavaliere, Riccardo
    Omero, Fausto
    Muscolino, Paola
    Granata, Barbara
    D'Anna, Federica
    Silvestris, Nicola
    De Pasquale, Claudia
    Ferlazzo, Guido
    Campana, Stefania
    CANCERS, 2023, 15 (11)
  • [28] A role for ILC2s, ILC3s and the NLRP3 inflammasome in different forms of asthma
    Umetsu, Dale T.
    Kim, Hye-Young
    Chang, Ya-Jen
    CYTOKINE, 2014, 70 (01) : 26 - 26
  • [29] ILC1s and ILC3s Exhibit Inflammatory Phenotype in Periodontal Ligament of Periodontitis Patients
    Li, Changyi
    Liu, Jianyue
    Pan, Jie
    Wang, Yuhui
    Shen, Lei
    Xu, Yan
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [30] The thin line between conventional dendritic cells (cDCs) and group 3 innate lymphoid cells (ILC3s) in the gut
    Antonova, Alina Ulezko
    Fachi, Jose Luis
    Gilfillan, Susan
    Colonna, Marco
    INTERNATIONAL IMMUNOLOGY, 2023, 35 (03) : 107 - 121
12345