A neuroprotective role of polyunsaturated fatty acids in C9orf72-ALS/FTD

被引：0
|
作者：
Dubey, Sandeep Kumar [1 ]
Bellen, Hugo J. [2 ,3 ,4 ]
机构：
[1] Baylor Coll Med, Dept Neurol, Houston, TX USA
[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
[3] Texas Childrens Hosp, Jan & Dan Duncan Neurol Res Inst, Houston, TX 77030 USA
[4] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA
来源：
NATURE NEUROSCIENCE | 2025年
关键词：
C9ORF72;
D O I：
10.1038/s41593-025-01920-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
New research shows that lipid metabolism genes are downregulated in patient samples and Drosophila models of amyotrophic lateral sclerosis or frontotemporal dementia associated with expansions in C9orf72, resulting in reduced levels of phospholipids containing polyunsaturated fatty acids. Importantly, increasing polyunsaturated fatty acids through diet or genetic modulation of C9orf72 in Drosophila or induced pluripotent stem cell-derived motor neurons significantly improves neuronal survival.
引用
收藏
页码：710 / 712
页数：3
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