Targeting mitochondrial function as a potential therapeutic approach for allergic asthma

被引：0

作者：

Chen, Daichi ^{[1
]}

Wu, Wanhua ^{[1
]}

Li, Jianing ^{[1
]}

Huang, Xueqin ^{[1
]}

Chen, Su ^{[2
]}

Zheng, Tingting ^{[1
]}

Huang, Gonghua ^{[1
]}

Ouyang, Suidong ^{[1
,2
]}

机构：

[1] Guangdong Med Univ, Dongguan Affiliated Hosp 1, Coll Med Technol, Guangdong Prov Key Lab Med Immunol & Mol Diagnost, Dongguan 523808, Peoples R China

[2] Liaobu Hosp Dongguan City, Dongguan 523430, Peoples R China

来源：

INFLAMMATION RESEARCH | 2025年 / 74卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Mitochondrial function; Allergic asthma; Pathogenesis; Therapeutic targets; CELL-DEATH; DYSFUNCTION; RETICULUM; RECEPTOR; KETONES; OBESITY; STRESS; INJURY; ALPHA; ACID;

D O I：

10.1007/s00011-024-01972-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Allergic asthma is a chronic complex airway disease characterized by airway hyperresponsiveness, eosinophilic inflammation, excessive mucus secretion, and airway remodeling, with increasing mortality and incidence globally. The pathogenesis of allergic asthma is influenced by various factors including genetics, environment, and immune responses, making it complex and diverse. Recent studies have found that various cellular functions of mitochondria such as calcium regulation, adenosine triphosphate production, changes in redox potential, and free radical scavenging, are involved in regulating the pathogenesis of asthma. This review explores the involvement of mitochondrial functional changes in the pathogenesis of asthma, and investigate the potential of targeting cellular mitochondria as a therapeutic approach for asthma. Those insights can provide a novel theoretical foundations and treatment strategies for understanding and preventing asthma.

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页数：11

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