Extraction, purification, structural characterization, and bioactivities of Radix Aconiti Lateralis Preparata (Fuzi) polysaccharides: A review

Radix Aconiti Lateralis Preparata (Fuzi) polysaccharide (FZP) is a key bioactive macromolecule derived from the root of Aconitum carmichaeli Debx. FZP has a variety of biological activities, including immunomodulatory, anti-tumor, anti-depressant, organ-protective, hypoglycemic, anti-inflammatory, and other activities. The biological activities of polysaccharides are closely related to their structures, and different extraction and purification methods will yield different polysaccharide structures. In this review, we summarized the advancements in FZP research, including extraction techniques, biological activities, and mechanism to provide basic reference for developing and applying as therapeutic agents and functional foods. At the same time, the shortcomings of FZP research are discussed in depth, and the potential development prospects and future research direction are prospected. © 2024 Elsevier B.V.