Synthesis of CoTMPyP/electrochemical reduction modified multi-walled carbon nanotubes nanocomposites for the detection of purines and uric acid

A [tetrakis(N-methylpyridyl)porphyrinato]cobalt electrochemical reduction modified multi-walled carbon nanotubes (CoTMPyP/ER-m-MWCNTs) nanocomposite was synthesized. The composites were characterized through an array of analytical techniques, including scanning electron microscopy, transmission electron microscopy, energy-dispersive spectroscopy, X-ray photoelectron spectroscopy, and Fourier-transform infrared spectroscopy. Electrochemical analyses demonstrated the capability of the CoTMPyP/ER-m-MWCNTs nanocomposite-modified glassy carbon electrode (GCE) to simultaneously detect adenine (A), guanine (G), and uric acid (UA) over specific concentration ranges: 0.41-63.71 mu M for uric acid, and 0.25-27.14 mu M for both adenine and guanine. The determined detection limits were 0.22 mu M, 0.24 mu M, and 0.32 mu M for adenine, guanine, and uric acid, respectively. The nanocomposite demonstrates significant promise for applications in electrochemical sensing.