AI-designed DNA sequences regulate cell-type-specific gene expression

被引：0
|
作者：
Pfenning, Andreas R. [1 ,2 ]
机构：
[1] Carnegie Mellon Univ, Computat Biol Dept, Pittsburgh, PA 15213 USA
[2] Carnegie Mellon Univ, Neurosci Inst, Pittsburgh, PA 15213 USA
来源：
NATURE | 2024年 / 634卷 / 8036期
关键词：
Genomics; Biotechnology; Synthetic biology; Machine learning;
D O I：
10.1038/d41586-024-03170-2
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Researchers have used artificial-intelligence models to create regulatory DNA sequences that drive gene expression in specific cell types. Such synthetic sequences could be used to target gene therapies to particular cell populations.
引用
收藏
页码：1059 / 1061
页数：3
相关论文
共 50 条
  • [1] DNA-SEQUENCES REGULATING CELL-TYPE-SPECIFIC AND HYPOXIA-INDUCIBLE EXPRESSION OF THE HUMAN ERYTHROPOIETIN GENE
    SEMENZA, GL
    KOURY, ST
    NEIFELT, MK
    CHI, SM
    GEARHART, JD
    ANTONARAKIS, SE
    AMERICAN JOURNAL OF HUMAN GENETICS, 1991, 49 (04) : 432 - 432
  • [2] DNA-SEQUENCES REGULATING CELL-TYPE-SPECIFIC AND HYPOXIA-INDUCIBLE EXPRESSION OF THE HUMAN ERYTHROPOIETIN GENE
    SEMENZA, GL
    KOURY, ST
    NEJFELT, MK
    CHI, SM
    GEARHART, JD
    ANTONARAKIS, SE
    PEDIATRIC RESEARCH, 1991, 29 (04) : A134 - A134
  • [3] Calcium and cell-type-specific gene expression in Dictyostelium
    Pinter, K
    Gross, J
    DIFFERENTIATION, 1995, 59 (04) : 201 - 206
  • [4] Freedom of expression: cell-type-specific gene profiling
    Otsuki, Leo
    Cheetham, Seth W.
    Brand, Andrea H.
    WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY, 2014, 3 (06) : 429 - 443
  • [5] REGULATION OF CELL-TYPE-SPECIFIC GENE-EXPRESSION IN DICTYOSTELIUM
    GOMER, RH
    DATTA, S
    MEHDY, M
    CROWLEY, T
    SIVERTSEN, A
    NELLEN, W
    REYMOND, C
    MANN, S
    FIRTEL, RA
    COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1985, 50 : 801 - 812
  • [6] Cell-type-specific epigenetic priming of gene expression by cocaine
    Mews, Philipp
    JOURNAL OF NEUROCHEMISTRY, 2022, 162 : 29 - 29
  • [7] GENE STRUCTURE AND CELL-TYPE-SPECIFIC EXPRESSION OF RAT HIPPOCALCIN
    KOBAYASHI, M
    TAKAMATSU, K
    SAITOH, S
    SAITOH, S
    KUROKI, T
    NOGUCHI, T
    JOURNAL OF NEUROCHEMISTRY, 1995, 65 : S101 - S101
  • [8] INTRAGENIC SEQUENCES ARE REQUIRED FOR CELL-TYPE-SPECIFIC AND INJURY-INDUCED EXPRESSION OF THE RAT PERIPHERIN GENE
    BELECKYADAMS, T
    WIGHT, DC
    KOPCHICK, JJ
    PARYSEK, LM
    JOURNAL OF NEUROSCIENCE, 1993, 13 (12): : 5056 - 5065
  • [9] INDUCTION AND MODULATION OF CELL-TYPE-SPECIFIC GENE-EXPRESSION IN DICTYOSTELIUM
    MEHDY, MC
    RATNER, D
    FIRTEL, RA
    CELL, 1983, 32 (03) : 763 - 771
  • [10] Identifying and mapping cell-type-specific chromatin programming of gene expression
    Marstrand, Troels T.
    Storey, John D.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (06) : E645 - E654
12345