Sodium azide (NaN3) intoxication, "the man who lived": potential effective antidote and treatment strategy

被引：0

作者：

Geerdink, Jasper X. ^{[1
,2
]}

van der Wal, Greetje ^{[1
,4
]}

de Jong, Lutea A. A. ^{[3
,5
]}

Olyslager, Erik J. H. ^{[3
,5
]}

van den Goorbergh, Thomas W. ^{[1
]}

Kluijtmans, Leo A. J. ^{[6
]}

Spronk, Peter E. ^{[1
,4
]}

机构：

[1] Gelre Hosp, Dept ICU, Apeldoorn, Netherlands

[2] Univ Med Ctr Utrecht, Utrecht, Netherlands

[3] Gelre Hosp Clin Pharm, Apeldoorn, Netherlands

[4] Expertise Ctr Intens Care Rehabil Apeldoorn ExpIRA, Apeldoorn, Netherlands

[5] Expertise Ctr TDM & Toxicol Gelre iLab, Apeldoorn, Netherlands

[6] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Translat Metab Lab, Nijmegen, Netherlands

来源：

CRITICAL CARE | 2025年 / 29卷 / 01期

关键词：

Sodium azide; NaN3; Levocarnitine; High-volume continuous veno-venous hemofiltration; HV-CVVH; CVVH; LACTATE CLEARANCE; INBORN-ERRORS; DIAGNOSIS;

D O I：

10.1186/s13054-025-05330-w

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

This case report describes the successful treatment of a suicide attempt involving the ingestion of a supralethal dose of sodium azide (NaN3), presenting a prospective novel antidote and therapeutic approach. Treatment encompassed the implementation of high-volume continuous veno-venous hemofiltration (HV-CVVH) alongside the administration of levocarnitine. The latter demonstrated a substantial mitigation of lactate concentration. Comprehensive analyses of serum, ultrafiltrate, and urine revealed the efficacy of HV-CVVH in elimination of NaN3. Our case report presents a potential therapeutic approach for managing otherwise fatal NaN3 intoxications.

引用

页数：6

共 24 条

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FEDERATION PROCEEDINGS, 1978, 37 (06) : 1455 - 1455
[23] The Effect of Ethyl Methane Sulphomate (EMS) and Sodium Azide (NaN3) on Plant Regeneration Capacity of an Embryogenic Cell Suspension of 'Yueyoukang 1' (Musa, AAA), a Banana Cultivar Resistant to Fusarium Wilt
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INTERNATIONAL ISHS-PROMUSA SYMPOSIUM ON GLOBAL PERSPECTIVES ON ASIAN CHALLENGES, 2011, 897 : 301 - 302
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Otaegui, Laida
Lopez del Amo, Juan Miguel
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Singh, Gurpreet
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