Alterations in center-surround contrast suppression in patients with major depressive disorder

被引:0
|
作者
Nickel, Kathrin [1 ]
Heinrich, Sven P. [2 ]
Beringer, Malina [1 ]
Endres, Dominique [1 ]
Runge, Kimon [1 ]
Kuechlin, Sebastian [2 ]
Maier, Simon [1 ]
Bach, Michael [2 ]
Domschke, Katharina [1 ,3 ]
Tebartz van Elst, Ludger [1 ]
Friedel, Evelyn B. N. [1 ,2 ,4 ]
机构
[1] Univ Freiburg, Med Ctr, Fac Med, Dept Psychiat & Psychotherapy, Freiburg, Germany
[2] Univ Freiburg, Fac Med, Eye Ctr, Med Ctr, Freiburg, Germany
[3] German Ctr Mental Hlth DZPG, Partner Site Berlin, Berlin, Germany
[4] Univ Freiburg, Fac Biol, Freiburg, Germany
来源
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词
Depression; Contrast suppression; Center-surround contrast suppression; Contrast sensitivity; Retina; TRANSGENE EXPRESSION; GENE-EXPRESSION; BASAL GANGLIA; HUNTINGTONS-DISEASE; DOPAMINE; BRAIN; BACTERIAL; NEURONS; PROMOTERS; SUBTYPES;
D O I
10.1038/s41598-024-78584-z
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Previous pattern electroretinogram studies indicate reduced retinal contrast gain in patients with a major depressive disorder (MDD) which may contribute to alterations in visual perception. In line, psychophysical investigations reported elevated contrast thresholds in MDD. This study aims to gain insights into higher-level processing of visual information in MDD by evaluating contrast suppression. We examined contrast suppression of 21 MDD patients and 23 healthy controls (HC) using four different stimulus conditions (spatial frequencies 6.3 and 12.6 cpd at 30% and 60% background contrast) in a psychophysical test. Participants were instructed to adjust perceived contrasts between two vertical target patches, embedded in a horizontally or vertically oriented grid background. With finer stimulus gratings, MDD patients exhibited less contrast suppression compared to HC, particularly when the stimulus contrast was high (p = 0.006; MDD vs. HC = - 45%). Contrast suppression in the HC group was significantly reduced for the coarse compared to the fine grating, while contrast suppression scores in MDD did not change with the spatial properties of the stimulus. The reduced contrast suppression in patients with MDD supports the hypothesis of altered dopaminergic neurotransmission and could be attributed to alterations in the retinal receptive fields or in dysfunctional adaptation mechanisms in depression.
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页数:10
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