Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not

被引：0

作者：

Kiyoko Iwatsuki-Horimoto ^{[1
]}

Maki Kiso ^{[2
]}

Mutsumi Ito ^{[1
]}

Seiya Yamayoshi ^{[2
]}

Yoshihiro Kawaoka ^{[1
]}

机构：

[1] University of Tokyo,Division of Virology, Institute of Medical Science

[2] University of Tokyo,The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA)

[3] National Center for Global Health and Medicine Research Institute,The Research Center for Global Viral Diseases

[4] University of Tokyo,Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science

[5] University of Wisconsin-Madison,Department of Pathobiological Sciences, Influenza Research Institute, School of Veterinary Medicine

来源：

npj Viruses | / 2卷 / 1期

关键词：

D O I：

10.1038/s44298-024-00068-8

中图分类号：

学科分类号：

摘要：

Syrian hamster are sensitive to SARS-CoV-2 and widely used as an animal model of COVID-19. In contrast, mice are not readily infected by the ancestral strains of SARS-CoV-2 because of differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Thus, even among rodents, susceptibility to SARS-CoV-2 varies. Knowledge of virus transmissibility from humans to pet rodents is important for public health to assess the potential for transmission in the home and pet breeding and selling facilities. In this study, we assessed the sensitivity of guinea pigs and gerbils to SARS-CoV-2 isolated from humans, and found that gerbils are susceptible to SARS-CoV-2, but guinea pigs are not. Pet sellers often display hamsters with high susceptibility to SARS-CoV-2 in the same area as gerbils, so caution should be exercised during COVID-19 outbreaks.

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