Copper-Catalyzed [3+2] Annulation of O-Acyl Oximes with p-Hydroquinones for the Synthesis of 5-Hydroxyindoles

被引：0

作者：

Zhang, Hui-Peng ^{[1
]}

Chen, Wei ^{[2
]}

Hu, Zi-Jun ^{[1
]}

Lyu, Xinyu ^{[1
]}

Qiao, En-Jun ^{[1
]}

Jin, Wan-Bo ^{[1
]}

Xu, Wen-Ya ^{[1
]}

Ding, Xian-Heng ^{[1
]}

Miao, Chun-Bao ^{[1
]}

Yang, Hai-Tao ^{[1
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Jiangsu, Peoples R China

[2] Changzhou Siyao Pharmaceut Co Ltd, Changzhou 213018, Jiangsu, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 20期

关键词：

QUINONES; ACETATES;

D O I：

10.1021/acs.joc.4c01722

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed [3 + 2] annulation of O-acyl oximes with 2-electron-withdrawing group substituted p-hydroquinones for the efficient synthesis of polysubstituted 5-hydroxyindoles is developed. Further intramolecular cyclization leads to the concise and rapid construction of several kinds of 3,4- and 4,5-fused polycyclic indoles.

引用

页码：14968 / 14980

页数：13

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