Magnesium alloys, renowned for their lightweight characteristics and structural advantages, often encounter limitations in formability and exhibit mechanical anisotropy due to the predominant basal texture resulting from conventional rolling processes. To address these challenges, cross-rolling has emerged as a highly effective technique to refine the microstructure, mitigate basal texture intensity, and enhance isotropy. In this work, highperformance ZE21B magnesium alloy sheets were successfully manufactured using a two-stage cross-rolling process. A comprehensive analysis was conducted to examine the evolution of the microstructure, texture modification, and mechanical properties. The cross-rolling process resulted in a refined grain structure and the development of a "circular TD-Split texture," which markedly reduced anisotropy. The resulting 150 mu m thick sheets demonstrated outstanding mechanical properties, with a yield strength of 270.1 MPa, an ultimate tensile strength of 337.1 MPa, and an elongation at break of 30.1 %. This study underscores the potential of cross-rolling as a method to produce isotropic, high-strength magnesium alloy sheets that are well-suited for advanced engineering applications.