Impact of Senescent Cell-Derived Extracellular Vesicles on Innate Immune Cell Function

被引：0
|
作者：
Chen, Yung-Yi [1 ]
Sullivan, Jack [1 ,2 ]
Hanley, Shaun [1 ]
Price, Joshua [1 ]
Tariq, Mohammad A. [1 ]
McIlvenna, Luke C. [3 ]
Whitham, Martin [3 ,4 ]
Sharma-Oates, Archana [5 ]
Harrison, Paul [1 ]
Lord, Janet M. [1 ,2 ,4 ,6 ]
Hazeldine, Jon [1 ,2 ]
机构：
[1] Institute of Inflammation and Ageing, University of Birmingham, Birmingham,B15 2TT, United Kingdom
[2] Scar Free Foundation Centre for Conflict Wound Research, University Hospitals Birmingham, Birmingham,B15 2GW, United Kingdom
[3] School of Sport, Exercise and Rehabilitation Science, University of Birmingham, Birmingham,B15 2TT, United Kingdom
[4] MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham,B15 2TT, United Kingdom
[5] School of Biosciences, University of Birmingham, Birmingham,B15 2TT, United Kingdom
[6] NIHR Birmingham Biomedical Research Centre, University Hospital Birmingham and University of Birmingham, Birmingham,B15 2TH, United Kingdom
来源：
Advanced Biology | 2024年 / 8卷 / 12期
基金：
英国医学研究理事会;
关键词：
Cell culture - Cell death - Immune system;
D O I：
10.1002/adbi.202400265
中图分类号：
学科分类号：
摘要：
Extracellular vesicles (EVs) are components of the senescence-associated secretory phenotype (SASP) that influence cellular functions via their cargo. Here, the interaction between EVs derived from senescent (SEVs) and non-senescent (N-SEVs) fibroblasts and the immune system is investigated. Via endocytosis, SEVs are phagocytosed by monocytes, neutrophils, and B cells. Studies with the monocytic THP-1 cell line find that pretreatment with SEVs results in a 32% (p © 2024 The Author(s). Advanced Biology published by Wiley-VCH GmbH.
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