Mechanical properties and development of silver Nanoparticle-enhanced Alginate-polyacrylamide double network Hydrogel

This study investigates the enhancement of mechanical properties in a sodium alginate-polyacrylamide double network (DN) nanocomposite hydrogel enhanced with silver nanoparticles (Alg-g-PAAm/nAg). This hydrogel utilizes both thermal and ionic cross-linking methods (MBA and CaCl2) to develop a robust matrix with outstanding mechanical and thermal properties. The Alg-g-PAAm/nAg DN nanocomposite hydrogel demonstrated a fracture stress of 1255 kPa, an elastic modulus of 200 kPa, and an exceptional toughness value of 520,000 kJ/m(3). Furthermore, the material's response to swelling in various pH and temperatures was analyzed through swelling studies, revealing significant pH sensitivity. The incorporation of silver nanoparticles (Ag NPs) within the nanocomposite significantly enhanced both its mechanical strength and stability, as well as its antibacterial performance. Antimicrobial assays against Staphylococcus aureus and Escherichia coli demonstrated pronounced inhibition zones, indicating the hydrogel's potent antibacterial properties. This dual enhancement makes the composite highly suitable for various demanding biomedical applications. The comprehensive analytical techniques employed, including FT-IR, FE-SEM, TEM, and TGA, confirmed the successful integration of the Ag NPs within the nanocomposite structure and underscored the material's potential in fields such as tissue engineering, drug delivery systems, and advanced wound dressings.