Metal-Free Diversification of Unprotected Amino Acid Drugs via Tandem Reaction of 2-(2-oxo-2-aryl/alkylethyl)benzonitrile in Aqueous Medium

被引：0
|
作者：
Sharma, Himanshi [1 ]
Kumar, Manoj [1 ]
Raj Bhatt, Padam [1 ]
Singh, Priyamvada [2 ]
Rathi, Brijesh [1 ]
机构：
[1] Univ Delhi, Hansraj Coll, Dept Chem, Lab Translat Chem & Drug Discovery, Delhi 110007, India
[2] Univ Delhi, Dept Chem, Miranda House, Delhi 110007, India
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2024年 / 30卷 / 61期
关键词：
Metal-free; Green solvent; Isoquinoline; Unprotected amino acid; Modification of drugs; LONG-LIVED CATALYSTS; ARYL CHLORIDES; IN-VITRO; HETEROARYL;
D O I：
10.1002/chem.202402214
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we report an efficient strategy towards the synthesis of amino acid substituted isoquinoline derivatives via reaction of unprotected amino acid/amino acid ester/amino acid based drugs with 2-(2-oxo-2-aryl/alkylethyl)benzonitrile under metal-free conditions. The developed protocol is highly simple and shows functional group tolerance to provide corresponding novel amino acid substituted isoquinolines in aqueous medium. The applicability of the reaction is an easier modification of well-known drugs and successfully extended to gram-scale synthesis.
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页数：5
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