Study on the regulatory effect of low intensity retinal ultrasound stimulation on the neural activity of visual cortex

被引：0
|
作者：
Wang, Qianqian [1 ,2 ]
Yuan, Yi [1 ,2 ]
Yan, Jiaqing [3 ]
机构：
[1] School of Electrical Engineering, Yanshan University, Hebei, Qinhuangdao,066004, China
[2] Key Laboratory of Intelligent Rehabilitation and Neuromodulation of Hebei Province, Yanshan University, Hebei, Qinhuangdao,066004, China
[3] College of Electrical and Control Engineering, North China University of Technology, Beijing,100041, China
来源：
Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering | 2024年 / 41卷 / 06期
关键词：
Low-intensity ultrasound stimulation of the retina has the ability to modulate neural activity in the primary visual cortex (V1); however; it is currently unclear how different intensities and durations of ultrasonic stimulation of the retina modulate neural activity in V1. In this paper; we recorded local field potential (LFP) signals in the V1 brain region of mice under different ultrasound intensities and different stimulation times. The amplitude of LFP corresponding to 1 s before ultrasound stimulation to 2 s after stimulation (–1–2 s) was analyzed; including the power and sample entropy of delta; theta; alpha beta; and low gamma frequency bands. The experimental results showed that; as the stimulation intensity increased; the peak value of the LFP in the visual cortex showed a linear upward trend; the power in the delta and theta frequency bands showed a linear upward trend; and the sample entropy showed a linear downward trend. With increases of stimulation duration; the peak value of the LFP in the visual cortex showed an upward trend; and the upward trend gradually weakened; the power in the delta frequency band showed an upward trend; the sample entropy showed a linear upward trend; and the sample entropy in the theta frequency band showed a downward trend. The results show that low-intensity ultrasonic stimulation of the retina has a significant modulatory effect on neural activity in the visual cortex. The study provides insights into the mechanisms by which ultrasonic stimulation regulates visual system function. Furthermore; it clarifies the patterns of parameter selection; facilitating the development of personalized multi-parameter modulation for the treatment of visual neural degeneration; retinal disorders and related research areas. © 2024 West China Hospital; Sichuan Institute of Biomedical Engineering. All rights reserved;
D O I：
10.7507/1001-5515.202401047
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页码：1161 / 1168
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