Exploring the interaction of hesperetin-mediated green synthesised gold and silver nanoparticles with human serum albumin: A comparative analysis

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作者：
Raj, Aparna [1 ]
Vidya, L. [1 ]
Vipina Vinod, T.N. [2 ]
Neelima, S. [1 ]
Aparna, V.M. [1 ]
Radhakrishnan, E.K. [2 ]
Sudarsanakumar, C. [1 ]
机构：
[1] School of Pure and Applied Physics, Mahatma Gandhi University, P.D Hills (P.O), Kerala, Kottayam,686 560, India
[2] School of Biosciences, Mahatma Gandhi University, P.D Hills (P.O), Kerala, Kottayam,686 560, India
来源：
Journal of Molecular Liquids | 2024年 / 416卷
关键词：
This study focused on evaluating the potential of hesperetin-functionalized silver (H-AgNPs) and gold nanoparticles (H-AuNPs) for biomedical use; with a primary objective of understanding their relative binding affinity to human serum albumin (HSA). We evaluated the strength and possible binding mechanisms of the interaction between the nanoparticles and HSA based on analyses from fluorescence studies; UV–visible absorption; lifetime measurements and isothermal titration calorimetry (ITC). Circular dichroism analysis was employed to examine the conformational changes in HSA upon complexation with H-AgNPs and H-AuNPs. Furthermore; the thermodynamic parameters derived from ITC provided insights into the stabilising forces driving the endothermic binding processes. Consistently; the binding constants derived from spectroscopic and calorimetric investigations elucidated the superior binding efficiency of H-AuNPs compared to H-AgNPs with HSA. Antibacterial study revealed that H-AgNPs exhibited significant activity against S. aureus and E. coli; revealing promising antibacterial effects. Contrarily; H-AuNPs demonstrated no activity in the study. From the MTT assay results; we observed that H-AgNPs exhibited higher anticancer activity against human lung cancer cells compared to H-AuNPs; while H-AuNPs demonstrated lower cytotoxicity than H-AgNPs. Based on our research findings; both nanoparticles hold promise as potential candidates for diverse applications in the therapeutic field. © 2024 Elsevier B.V;
D O I：
10.1016/j.molliq.2024.126488
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