Synthesis of oxa-bridged carbocycles via rhodium/Lewis acid catalyzed [3 + 3] and [4 + 3] cycloadditions of carbonyl ylides with donor–acceptor strained carbocycles

被引：0

作者：

Li, Jiale ^{[1
]}

Wang, Lingfei ^{[1
]}

Liu, Pei-Nian ^{[1
,2
]}

Li, Xingguang ^{[1
]}

机构：

[1] Shanghai Key Laboratory of Functional Materials Chemistry, Key Laboratory for Advanced Materials, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai,200237, China

[2] State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing,210009, China

来源：

Organic Chemistry Frontiers | / 12卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Catalysis; -; Cycloaddition;

D O I：

10.1039/d4qo01831a

中图分类号：

学科分类号：

摘要：

A method for cooperative rhodium/Lewis acid-catalyzed [3 + 3] and [4 + 3] cycloadditions of carbonyl ylides with donor–acceptor (D–A) strained carbocycles is described. It affords access to a wide range of structurally diverse oxa-bridged carbocycles with high efficiency and stereoselectivity. This method operates under mild conditions, exhibits good step and atom economy, and can be extended to [3 + 2] cycloadditions with D–A 1,2-dipoles, enabling the construction of oxa-bridged spirocycles. © the Partner Organisations 2025.

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页码：491 / 496

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