Photocatalyst-free regioselective sulfonamidation of N-(2-hydroxyaryl)amides in visible-light

被引：0

作者：

Rajat, Shruti ^{[1
]}

Rajput, Shruti ^{[1
]}

Grover, Nitika ^{[1
]}

Jain, Nidhi ^{[1
]}

机构：

[1] Indian Inst Technol Delhi, Dept Chem, New Delhi 110016, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 43期

关键词：

HYPERVALENT; REAGENTS; BOND;

D O I：

10.1039/d4ob01393j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this work, we report a regioselective sulfonamidation of N-(2-hydroxyaryl)amides with iminoiodinanes and iodine in visible light at room temperature. The method does not require a strong oxidant, metal or photocatalyst and enables direct functionalization of a C-H bond to a C-N bond. Mechanistic investigations suggest in situ generation of an N-centered radical from N,N-diiodo-sulfonamide by homolytic N-I bond cleavage followed by its site-specific addition to N-(2-hydroxyaryl)amides to furnish para-sulfonamide derivatives.

引用

页码：8649 / 8655

页数：7

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