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- [1] SYNTHESIS AND BIOLOGICAL EVALUATION OF N-[4-(2-TRANS-[([2,6-DIAMINO-4(3H)-OXOPYRIMIDIN-5-YL]METHYL)THIO]CYCLOBUTYL)BENZOYL]-L-GLUTAMIC ACID A NOVEL 5-THIAPYRIMIDINONE INHIBITOR OF DIHYDROFOLATE-REDUCTASEJOURNAL OF HETEROCYCLIC CHEMISTRY, 1995, 32 (05) : 1493 - 1498VARNEY, MDROMINES, WHBORITZKI, TMARGOSIAK, SABARTLETT, CHOWLAND, EJ
- [2] Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agentsJOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (23) : 7215 - 7222Gangjee, ALin, XKisliuk, RLMcGuire, JJ
- [3] Synthesis and biological evaluation of a new series of dihydrofolate reductase inhibitors based on the 4-(2,6-diamino-5-pyrimidinyl)alkyl-L-glutamic acid structureBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (04) : 473 - 476Gossett, LSHabeck, LLGates, SBAndis, SLWorzalla, JFSchultz, RMMendelsohn, LGKohler, WRatnam, MGrindey, GBShih, CA
- [4] Design and synthesis of n-[4-[(2,4-diamino-5-methylpyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl]-l-glutamic acid as a classical DHFR inhibitorABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 223 : B130 - B130Gangjee, ALin, XMcGuire, JJ
- [5] Design and synthesis of N-[4-[(2,4-diamino-5-methylfuro[2,3D]dipyrimidin-6-yl)thio]benzoyl-L-glutamic acid as a classical dual inhibitor of TS and DHFR.ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U925 - U926Gangjee, AJain, HDQueener, SFKisliuk, RL
- [6] Design and synthesis of N-[4-(2,4-diamino-5-propyl-7H-pyrrolo [2,3-D] pyrimidin-6-ylsulfanyl)-benzoyl]-L-glutamic acid as a potent inhibitor of dihydrofolate reductase and as an antitumor agent.ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U197 - U197Gangjee, AJain, HQueener, SFKisliuk, RL
- [7] Design and synthesis of N-[4-(2,4-diamino-5-propyl-7H-pyrrolo[2,3-D]pyrimidin-6-ylsulfanyl)-benzoyl]-L-glutamic acid as a potent inhibitor of dihydrofolate reductase and as an antitumor agent.ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U203 - U203Gangjee, AJain, HQueener, SFKisliuk, RL
- [8] Synthesis of N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3-H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as potential dual inhibitor DHFR and TS.ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 : U198 - U198Gangjee, ALin, XMcGuire, JJKisliuk, RL
- [9] Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-L-glutamic acid diethyl ester:: Evaluation of in vitro anti-cancer and anti-folate activitiesEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (01) : 189 - 203Corona, PaolaLoriga, MarioCosti, M. PaolaFerrari, StefaniaPaglietti, Giuseppe
- [10] Synthesis and biological evaluation of N-{4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl)benzoyl}-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathwayBIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (10) : 3593 - 3599Cheng, HHwang, IChong, YHTavassoli, AWebb, MEZhang, YWilson, IABenkovic, SJBoger, DL