ESTIMATION ALGORITHMS FOR DYNAMIC TRACER STUDIES USING POSITRON-EMISSION TOMOGRAPHY.

被引：0
|
作者：
Ollinger, John M. [1 ]
机构：
[1] Washington Univ, St. Louis, MO, USA, Washington Univ, St. Louis, MO, USA
来源：
IEEE Transactions on Medical Imaging | 1987年 / MI-6卷 / 02期
关键词：
MATHEMATICAL STATISTICS - NUCLEAR MEDICINE;
D O I：
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中图分类号：
学科分类号：
摘要：
Algorithms are developed for estimating statistics for use by parameter estimation algorithms in dynamic tracer studies utilizing positron-emission tomography and requiring high temporal resolution. Two types of statistics are considered. One can be used with the expectation-maximization algorithm to compute maximum likelihood parameter estimates, and the other computes a histogram of activity levels versus time for use with weighted least-squares parameter estimation algorithms. An estimator of the variance of this histogram is given. Variants for use with both time-of-flight and projection data collected at high frame rates are presented. The algorithms account for the effects of attenuation, randoms, detector efficiency, and nonuniform sampling.
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页码：115 / 125
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