Purification and cloning of aggrecanase-1: A member of the ADAMTS family of proteins

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作者：
Tortorella, M.D.
Burn, T.C.
Pratta, M.A.
Abbaszade, I.
Hollis, J.M.
Liu, R.
Rosenfeld, S.A.
Copeland, R.A.
Decicco, C.P.
Wynn, R.
Rockwell, A.
Yang, F.
Duke, J.L.
Solomon, K.
George, H.
et al.
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Science | / 284卷 / 5420期
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摘要：
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4)] is a member of the ADAMTS protein family that cleaves aggrecan at the glutamic acid-373-alanine-374 bond. The identification of this protease provides a specific target for the development of therapeutics to prevent cartilage degradation in arthritis.
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页码：1664 / 1666
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