Expression of adherent molecule and cyclin by ligustrazine in bone marrow of mice with immune-induced aplastic anemia

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Dong, Lingli
Sun, Hangying
Liu, Wenli
Xu, Huizhen
Tao, Deding
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Journal of Tongji Medical University | / 19卷 / 01期
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Mice with immune-induced aplastic anemia (AA) were given 5 mg ligustrazine intraperitoneally twice a day. On the 14th day, the expression of CD49d, CD49c, cyclinD2 in bone marrow mononuclear cells (MNC) was examined by flow cytometry, and VCAM-1 on stromal cells was immunohistochemically measured by Strept Avidin-Biotin Complex (SABC). The expression of CD49d, CD49c, VCAM-1 and cyclinD2 in ligustrazine-treated group was significantly higher than that in AA group (P0+G1 phase cells was significantly lower than that in AA group (P2 in the bone marrow of mice with immune-induced aplastic anemia, thereby promoting the growth of hematopoietic cells.
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