Technetium-99m diethyldithiocarbamate (DDC): Comparison with thallium-201 DDC as an agent for brain imaging

Technetium-99m diethyldithiocarbamate (**9**9**mTc-DDC) was prepared by reduction of left bracket **9**9**m Tc right bracket pertechnetate with formamidine sulfinic acid in the presence of DDC at alkaline pH, both from extemporaneous solutions and in a kit formulation. The properties of **9**9**mTc-DDC were compared in vitro and in vivo with those of **2**0**1Tl-DDC, an agent used for cerebral perfusion imaging (CPI). **9**9**mTc-DDC is a lipophilic complex but its oil/water partition coefficient is lower than that of **2**0**1Tl-DDC. **9**9**mTc-DDC also shows greater binding to plasma proteins.