Technetium-99m diethyldithiocarbamate (DDC): Comparison with thallium-201 DDC as an agent for brain imaging

被引：0

作者：

Ballinger, J.R. ^{[1
]}

Gerson, B. ^{[1
]}

Gulenchyn, K.Y. ^{[1
]}

机构：

[1] Division of Nuclear Medicine, Ottawa Civic Hospital, Ottawa, Ont. K1Y 4E9, Canada

来源：

International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes | 1987年 / 38卷 / 08期

关键词：

BIOLOGICAL MATERIALS - Imaging Techniques - RADIOACTIVE MATERIALS - Tracers;

D O I：

10.1016/0883-2889(87)90136-5

中图分类号：

学科分类号：

摘要：

Technetium-99m diethyldithiocarbamate (**9**9**mTc-DDC) was prepared by reduction of left bracket **9**9**m Tc right bracket pertechnetate with formamidine sulfinic acid in the presence of DDC at alkaline pH, both from extemporaneous solutions and in a kit formulation. The properties of **9**9**mTc-DDC were compared in vitro and in vivo with those of **2**0**1Tl-DDC, an agent used for cerebral perfusion imaging (CPI). **9**9**mTc-DDC is a lipophilic complex but its oil/water partition coefficient is lower than that of **2**0**1Tl-DDC. **9**9**mTc-DDC also shows greater binding to plasma proteins.

引用

页码：665 / 668

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