On the restriction of the release of water-soluble component from polyvinyl alcohol film by blending β-cyclodextrin

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作者：
Sree Chitra Tirunal Inst for Medical, Sciences Technology, Trivandrum, India [1 ]
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来源：
J Appl Polym Sci | / 9卷 / 1829-1832期
关键词：
Aromatic polymers - Carboxylic acids - Composition effects - Controlled drug delivery - Polyvinyl alcohols;
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摘要：
The effect of adding β-Cyclodextrin with poly(vinyl alcohol) (PVA) hydrogel on the release of a water-soluble component has been investigated. It is found that the release of a model drug, salicyclic acid, from PVA matrix in the presence of β-cyclodextrin prolonged considerably the release of the profile of the drug from the PVA gel. The profound influence of β-cyclodextrin on the drug release has been assigned to the ability of β-cyclodextrin to form an inclusion complex with salicyclic acid.
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