Synthesis of 13C- and 14C-labeled 3-(dichloroacetyl)-5-(2-furanyl)- 2,2-dimethyloxazolidine

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Environmental Science Department, Ceregen, A Unit of Monsanto Company, St. Louis, MO 63198, United States [1 ]
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J. LABEL. COMPD. RADIOPHARM. | / 7卷 / 631-636期
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Cyanides; -; Potassium;
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摘要：
Synthesis of 3-(dichloroacetyl)-5-(2-furanyl)-2,2-dimethyloxazolidine (common name: furilazole) labeled with carbon-14 and carbon-13 are described. Two routes for the synthesis of labeled trimethylsilyl cyanide, a precursor to furilazole, are described. One method can be carried out on milligram scale and is suitable for a high specific activity preparation while the second method is suitable for preparation on grain scale. Carbon-14 labeled furilazole was obtain from isotopically labeled potassium cyanide in 5 steps with an overall yield of 28-34%.
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