Effect of 2-Methyl Substitution on the Stability of Spin Adducts Composed of Pyrroline N-Oxide Analogues and Superoxide Anion Radicals

被引：0

作者：

Xu, Ying-Kai ^{[1
]}

Sun, Jian ^{[1
]}

Liu, Ke ^{[1
]}

Chen, Zhong-Wei ^{[1
]}

Zhang, Xing-Kang ^{[1
]}

Liu, Yang ^{[1
]}

机构：

[1] State Key Lab. Struct. Chem. U., Center for Molecular Science, Chinese Academy of Sciences, Beijing, 100080, China

来源：

Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities | 2001年 / 22卷 / 10期

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The synthesis of a novel α-phosphorus-containing spin trap, DEPDMPO (5-diethoxy Phosphoryl-2, 5-dimethyl-1-pyrroline N-oxide) and the evaluation of its ability to spin-trap the hydroxyl and the superoxide anion radicals were described in the present article. The ability to trap an active superoxide anion radical generated in the photo system II (PSII) and the stability of their spin adduct of DEPDMPO as well as three previously reported traps DMPO, DEPMPO and M3PO were comparatively analyzed according to their chemical structures. In addition, the effects of 2-methyl and α-phosphoryl substituted analogues of DMPO on the stabilities of the corresponding spin adduts were systematically illustrated.

引用

页码：1732 / 1734

共 50 条

[41] SYNTHESIS AND SPIN-TRAPPING CHEMISTRY OF 5,5-DIMETHYL-2-(TRIFLUOROMETHYL)-1-PYRROLINE N-OXIDE
JANZEN, EG
ZHANG, YK
ARIMURA, M
JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (17): : 5434 - 5440
[42] 5-(DIETHOXYPHOSPHORYL)-5-METHYL-1-PYRROLINE N-OXIDE - A NEW EFFICIENT PHOSPHORYLATED NITRONE FOR THE IN-VITRO AND IN-VIVO SPIN-TRAPPING OF OXYGEN-CENTERED RADICALS
FREJAVILLE, C
KAROUI, H
TUCCIO, B
LEMOIGNE, F
CULCASI, M
PIETRI, S
LAURICELLA, R
TORDO, P
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (02) : 258 - 265
[43] 5-DIETHOXYPHOSPHORYL-5-METHYL-1-PYRROLINE N-OXIDE (DEPMPO) - A NEW PHOSPHORYLATED NITRONE FOR THE EFFICIENT IN-VITRO AND IN-VIVO SPIN-TRAPPING OF OXYGEN-CENTERED RADICALS
FREJAVILLE, C
KAROUI, H
TUCCIO, B
LEMOIGNE, F
CULCASI, M
PIETRI, S
LAURICELLA, R
TORDO, P
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1994, (15) : 1793 - 1794
[44] AN ENDOR STUDY OF RADICAL SPIN ADDUCTS DERIVED FROM NOVEL 2-SUBSTITUTED-5,5-DIMETHYL-PYRROLINE-N-OXIDE SPIN TRAPS
JANZEN, EG
ZHANG, YK
HAIRE, DL
KOTAKE, Y
PAYNE, M
APPLIED MAGNETIC RESONANCE, 1994, 6 (04) : 511 - 519
[45] TERNARY-SYSTEM COMPOSED OF H2O, N-METHYL MORPHOLIN N-OXIDE AND NASCN - ULTRASONIC INVESTIGATION
BERCHIESI, G
FARHAT, F
CASTELLANI, F
VITALI, G
JOURNAL OF MOLECULAR LIQUIDS, 1992, 51 (1-2) : 51 - 58
[46] Synthesis and Spin-Trapping Properties of a Trifluoromethyl Analogue of DMPO: 5-Methyl-5-trifluoromethyl-1-pyrroline N-Oxide (5-TFDMPO)
Karoui, Hakim
Nsanzumuhire, Celine
Le Moigne, Francois
Hardy, Micael
Siri, Didier
Derat, Etienne
Rockenbauer, Antal
Ouari, Olivier
Tordo, Paul
CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (14) : 4064 - 4071
[47] Spin adducts of several N-2-(2-alkoxycarbonyl-propyl)-α-pyridylnitrone derivatives with superoxide, alkyl and lipid-derived radicals
Stolze, K
Udilova, N
Rosenau, T
Hofinger, A
Nohl, H
BIOCHEMICAL PHARMACOLOGY, 2004, 68 (01) : 185 - 193
[48] 31P-labeled pyrroline N-oxides:: Synthesis of 5-diethylphosphono-5-methyl-1-pyrroline N-oxide (DEPMPO) by oxidation of diethyl (2-methylpyrrolidin-2-yl)phosphonate
Barbati, S
Clément, JL
Fréjaville, C
Bouteiller, JC
Tordo, P
Michel, JC
Yadan, JC
SYNTHESIS-STUTTGART, 1999, (12): : 2036 - 2040
[49] Stability of 5,5-dimethyl-1-pyrroline-N-oxide as a spin-trap for quantification of hydroxyl radicals in processes based on Fenton reaction
Fontmorin, J. M.
Castillo, R. C. Burgos
Tang, W. Z.
Sillanpaa, M.
WATER RESEARCH, 2016, 99 : 24 - 32
[50] Using anti-5,5-dimethyl-1-pyrroline N-oxide (anti-DMPO) to detect protein radicals in time and space with immuno-spin trapping
Mason, RP
FREE RADICAL BIOLOGY AND MEDICINE, 2004, 36 (10) : 1214 - 1223

← 1 2 3 4 5 →