Synergistic antibacterial study of Cu2O/CuO-tetracycline composites

被引：0
|
作者：
Wu Y. [1 ,2 ]
Chen H. [1 ,2 ]
Fang X. [1 ,2 ]
Ji X. [1 ,2 ]
Guo S. [1 ,2 ]
Xu H. [1 ,2 ]
Li L. [1 ,2 ]
机构：
[1] Shaanxi Key Laboratory of Catalysis, School of Chemical & Environment Science, Shaanxi University of Technology, Hanzhong
[2] State Key Laboratory of Qinba Bio-Resource and Ecological Environment, Shaanxi University of Technology, Hanzhong
来源：
Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica | 2023年 / 40卷 / 12期
关键词：
bacteriostatic mechanism; composite material; Cu[!sub]2[!/sub]O/CuO; medical materials; synergistic bacterial inhibition; tetracycline;
D O I：
10.13801/j.cnki.fhclxb.20230417.004
中图分类号：
学科分类号：
摘要：
The rapid growth of drug-resistant bacteria and the lack of availability of new treatment strategies make it urgent for people to develop new bacteriostatic agents to solve such problems. In this study, copper nitrate trihydrate [Cu(NO3)2·3H2O] was used as a raw material and hydrazine hydrate as a reducing agent to prepare cuprous oxide (Cu2O/CuO), then Cu2O/CuO-tetracycline composites were obtained by combining them with tetracycline. Systematic characterization of inhibitors was conducted using TEM, XRD, XPS, FTIR, and UV-vis. The inhibitory properties and mechanism of Cu2O/CuO-tetracycline on the Gram-positive bacterium Staphylococcus aureus (S. aureus), Gram-negative bacterium Escherichia coli (E. coli), and drug-resistant bacterium Salmonella (T-Salmonella) were studied. The results of antibacterial properties show that the antibacterial rate of Cu2O/CuO-tetracycline composites with antibacterial concentration of 150 µg/mL to E. coli, S. aureus, and T-Salmonella reached 99.99% at 80 min. Compared with tetracycline and Cu2O/CuO alone, the antibacterial efficiency of Cu2O/CuO-tetracycline composite increase by 2.50 and 1.38 times for E. coli, 1.58 and 1.18 times for S. aureus and 1.26 and 1.12 times for T-Salmonella, respectively. In a word, Cu2O/CuO-tetracycline composites are the most sensitive to E. coli. The antibacterial mechanism shows that the composite material can effectively destroy the bacterial cell wall, change the membrane permeability, and finally make the bacteria rupture and die. The Cu2O/CuO-tetracycline composites have excellent antibacterial properties, indicating their wide application prospects in the fields of medical devices and medical materials. © 2023 Beijing University of Aeronautics and Astronautics (BUAA). All rights reserved.
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页码：6789 / 6799
页数：10
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