Iridium-catalyzed addition of acid chlorides to terminal alkynes

被引：0
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作者：
Iwai, Tomohiro [1 ]
Fujihara, Tetsuaki [1 ]
Terao, Jun [1 ]
Tsuji, Yasushi [1 ]
机构：
[1] Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
来源：
Journal of the American Chemical Society | 2009年 / 131卷 / 19期
关键词：
(Chemical Equation Presented) An iridium N-heterocyclic carbene (NHC) complex, IrCl(cod)(IPr), successfully catalyzed an addition of common aromatic acid chlorides to terminal alkynes to afford (Z)-β-chloro-α,β- unsaturated ketones regio- and stereoselectively. When the NHC ligand (IPr) was changed to a phosphine (RuPhos), the addition occurred with decarbonylation to give the corresponding (Z)-vinyl chlorides. Furthermore, the former reaction using IrCl(cod)(IPr) can be applied to the catalytic synthesis of 2,5-disubstituted furans. Copyright © 2009 American Chemical Society;
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页码：6668 / 6669
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