A dual-targeted trinity of antibody-peptide-drug delivery consortium to combat HER2+tumor

被引：0

作者：

Shang, Yuna ^{[1
]}

Wang, Jiayu ^{[1
]}

Feng, Yinyin ^{[1
]}

Liu, Zhengyu ^{[1
]}

Lu, Jiayi ^{[1
]}

Deng, Sijia ^{[4
]}

Li, Li ^{[1
]}

Zhang, Hongxu ^{[1
]}

Li, Liantao ^{[4
]}

Wang, Zhongyan ^{[3
]}

Yang, Zhimou ^{[2
,4
]}

机构：

[1] Tianjin Normal Univ, Acad Interdisciplinary Studies Intelligent Mol, Coll Chem, Tianjin Key Lab Struct & Performance Funct Mol, Tianjin 300387, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 1, Zhejiang Key Lab Intelligent Canc Biomarker Discov, Wenzhou 325035, Zhejiang, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Tianjin Inst Hlth Sci, Inst Radiat Med, State Key Lab Adv Med Mat & Devices,Tianjin Key La, Tianjin 300192, Peoples R China

[4] Xuzhou Med Univ, Affiliated Hosp, Ctr Clin Oncol, Jiangsu Ctr Collaborat & Innovat Canc Biotherapy, Xuzhou 221004, Jiangsu, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 93期

基金：

中国国家自然科学基金;

关键词：

Self assembly;

D O I：

10.1039/d4cc05115g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We pioneered a dual-targeted trinity of antibody-peptide-drug delivery consortium to combat HER2+ tumors. This innovative approach leverages the self-assembly of peptides with high affinity to antibodies to create nanofibers for antibody encapsulation, offering a novel strategy in antibody drug delivery.

引用

页码：13742 / 13745

页数：4

共 32 条

[1] Supramolecular Nanofibers of Drug-Peptide Amphiphile and Affibody Suppress HER2+Tumor Growth
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[4] Cascade Downregulation of the HER Family by a Dual-Targeted Recombinant Protein-Drug Conjugate to Inhibit Tumor Growth and Metastasis
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[8] Dual-targeted delivery of temozolomide by multi-responsive nanoplatform via tumor microenvironment modulation for overcoming drug resistance to treat glioblastoma
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[9] Peptide-drug conjugate designated for targeted delivery to HER2-expressing cancer cells
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[10] Tumor-targeted gene delivery via anti-HER2 antibody (trastuzumab, Herceptin®) conjugated polyethylemmine
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