Inhibition of tobacco bacterial wilt with sulfone derivatives containing an 1,3,4-oxadiazole moiety

被引：0

作者：

机构：

[1] Xu, Wei-Ming

[2] Han, Fei-Fei

[3] He, Ming

[4] Hu, De-Yu

[5] He, Jiang

[6] Yang, Song

[7] Song, Bao-An

来源：

Yang, S. (fcc.syang@gzu.edu.cn) | 1600年 / American Chemical Society卷 / 60期

关键词：

A series of new sulfone compounds containing the 1,3,4-oxadiazole moiety were designed and synthesized. Their structures were identified by 1H and 13C nuclear magnetic resonance and elemental analyses. Antibacterial bioassays indicated that most compounds exhibited promising in vitro antibacterial bioactivities against tobacco bacterial wilt at 200 μg/mL. The relationship between structure and antibacterial activity was also discussed. Among the title compounds, 5′c, 5′h, 5′i, and 5′j could inhibit mycelia growth of Ralstonia solanacearum in vitro by approximately 50% (EC50) at 39.8, 60.3, 47.9, and 32.1 μg/mL, respectively. Among them, compound 5′j was identified as the most promising candidate due to its stronger effect than that of Kocide 3000 [Cu(OH)2] within the same concentration range. Field trials demonstrated that the control effect of compound 5′j against tobacco bacterial wilt was better than that of the commercial bactericide Saisentong. For the first time, the present work demonstrated that sulfone derivatives containing 1,3,4-oxadiazole can be used to develop potential bactericides for plants. © 2011 American Chemical Society;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Journal article (JA)

引用

共 50 条

[31] Photophysics of Fluorene Copolymers Containing 1,3,4-Oxadiazole or 1,3,4-Oxadiazole and Carbazole Units
de Miguel, Maykel
Alvaro, Mercedes
Ding, Jianfu
Garcia, Hermenegildo
JOURNAL OF PHYSICAL CHEMISTRY C, 2010, 114 (33): : 14255 - 14260
[32] Synthesis and Antimicrobial Properties of 1,3,4-Oxadiazole Analogs Containing Dibenzosuberane Moiety
Moger, Manjunath
Satam, Vijay
Govindaraju, Darshan Raj C.
Paniraj, A. S.
Gopinath, Vadiraj S.
Hindupur, Rama Mohan
Pati, Hari N.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2014, 25 (01) : 104 - 111
[33] Synthesis and Biological Activities of Novel Cyanoacrylates Containing 1,3,4-Oxadiazole Moiety
Shi, Yujn
Li, Yang
Fang, Yuan
Chen, Jia
Ye, Linyu
Ge, Shushan
Dai, Hong
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 36 (10) : 2472 - 2478
[34] Trifluoromethylpyridine 1,3,4-Oxadiazole Derivatives: Emerging Scaffolds as Bacterial Agents
Yu, Gang
Chen, Shunhong
Guo, Shengxin
Xu, Bixue
Wu, Jian
ACS OMEGA, 2021, 6 (46): : 31093 - 31098
[35] Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety
Liu, Fang
Luo, Xiao-Qiong
Song, Bao-An
Bhadury, Pinaki S.
Yang, Song
Jin, Lin-Hong
Xue, Wei
Hu, De-Yu
BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (07) : 3632 - 3640
[36] Synthesis and bioactivity of sulfide derivatives containing 1,3,4-oxadiazole and pyridine
Yu, Gang
Chen, Shunhong
He, Feng
Luo, Dexia
Zhang, Yu
Wu, Jian
TURKISH JOURNAL OF CHEMISTRY, 2019, 43 (04) : 1075 - 1085
[37] SYNTHESIS OF 1,3,4-OXADIAZOLE AMINOALKYL DERIVATIVES, CONTAINING INDOLE RADICALS
KELAREV, VI
SHVEKHGEIMER, GA
IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA I KHIMICHESKAYA TEKHNOLOGIYA, 1982, 25 (12): : 1458 - 1461
[38] Novel Cinnamic Acid Derivatives Containing the 1,3,4-Oxadiazole Moiety: Design, Synthesis, Antibacterial Activities, and Mechanisms
Wang, Shaobo
Chen, Jixiang
Shi, Jing
Wang, Zhijia
Hu, Deyu
Song, Baoan
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 69 (40) : 11804 - 11815
[39] SYNTHESIS OF NEW 1,3,4-OXADIAZOLE DERIVATIVES
GREKOV, AP
NESYNOV, EP
ZHURNAL OBSHCHEI KHIMII, 1961, 31 (04): : 1122 - &
[40] THERMAL REARRANGEMENT OF 1,3,4-OXADIAZOLE DERIVATIVES
MITRA, RB
KULKARNI, GH
SHIRWAIKER, GS
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1978, 16 (02): : 146 - 148

← 1 2 3 4 5 →