Nisin Z inhibits the growth of Candida albicans and its transition from blastospore to hyphal form

被引：0
|
作者：
Le Lay, C. [1 ,2 ]
Akerey, B. [1 ]
Fliss, I. [2 ]
Subirade, M. [2 ]
Rouabhia, M. [1 ,3 ]
机构：
[1] Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Québec, QC, Canada
[2] Faculté des Sciences de l'Agriculture et de l'Alimentation, Département des Sciences des Aliments et de Nutrition, Université Laval, Québec, QC, Canada
[3] Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Université Laval, Québec, QC G1K 7P4, Canada
来源：
Journal of Applied Microbiology | 2008年 / 105卷 / 05期
关键词：
Aims: To investigate the efficacy of nisin Z; an antimicrobial peptide produced by certain strains of Lactococcus lactis against Candida albicans growth and transition. Methods and Results: Candida albicans was cultured in the presence of various concentrations of nisin Z (1000; 500; and 100 μg ml -1) for different time points. Candida albicans growth was determined using the Alamar Blue assay. The yeast's transition from blastospore to hyphal form was assessed through optical microscope observations. The effect of nisin Z on C. albicans ultrastructure was followed by scanning and transmission electron microscopy. Our results show that nisin Z inhibited C. albicans growth beginning at 500 μg ml-1. This inhibition was both time- and dose-dependent. Nisin Z was also active against C. albicans transition by significantly inhibiting the transformation of C. albicans from the blastospore to hyphal form. Treatments with nisin Z lead to ultrastructural disturbances of C. albicans. Conclusion: Our findings indicate that nisin Z significantly reduced C. albicans growth and transition. These effects may have occurred through ultrastructural modifications of this yeast. Significance and Impact of the Study: For the first time; effect of nisin Z on C. albicans was investigated. These results therefore suggest that nisin Z may have antifungal properties; and could be used as an antifungal molecule. © 2008 The Authors;
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页码：1630 / 1639
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