Stable lariat formation based on a G-quadruplex scaffold

被引：0
|
作者：
Xu, Yan [1 ]
Sato, Hiroyuki [1 ]
Sannohe, Yuta [1 ]
Shinohara, Ken-Ichi [1 ]
Sugiyama, Hiroshi [1 ]
机构：
[1] Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto, 606-8502, Japan
来源：
Journal of the American Chemical Society | 2008年 / 130卷 / 49期
关键词：
In the telomere region; T-loop structure is thought to participate in protecting chromosome ends. Although the tetraplex structure; called G-quadruplex; is suggested to form in the same region; the relationship between these two structures are less discussed. Here we designed the long lariat formation using G-quadruplex structure. The structural property was characterized by means of CD spectroscopy; FRET experiment; and native PAGE analysis. Because this lariat formation contains both loop structure and tetraplex structure; it can be a key structure linking T-loop structure to G-quadrurplex structure. Copyright © 2008 American Chemical Society;
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摘要：
Journal article (JA)
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页码：16470 / 16471
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