Stable lariat formation based on a G-quadruplex scaffold

被引：0
|
作者：
Xu, Yan [1 ]
Sato, Hiroyuki [1 ]
Sannohe, Yuta [1 ]
Shinohara, Ken-Ichi [1 ]
Sugiyama, Hiroshi [1 ]
机构：
[1] Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto, 606-8502, Japan
来源：
Journal of the American Chemical Society | 2008年 / 130卷 / 49期
关键词：
In the telomere region; T-loop structure is thought to participate in protecting chromosome ends. Although the tetraplex structure; called G-quadruplex; is suggested to form in the same region; the relationship between these two structures are less discussed. Here we designed the long lariat formation using G-quadruplex structure. The structural property was characterized by means of CD spectroscopy; FRET experiment; and native PAGE analysis. Because this lariat formation contains both loop structure and tetraplex structure; it can be a key structure linking T-loop structure to G-quadrurplex structure. Copyright © 2008 American Chemical Society;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Journal article (JA)
引用
收藏
页码：16470 / 16471
相关论文
共 50 条
  • [1] Stable Lariat Formation Based on a G-Quadruplex Scaffold
    Xu, Yan
    Sato, Hiroyuki
    Sannohe, Yuta
    Shinohara, Ken-ichi
    Sugiyama, Hiroshi
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (49) : 16470 - +
  • [2] Sequence requirement for formation of stable G-quadruplex structures.
    Joseph, A
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U179 - U179
  • [3] A benzimidazopyridoquinoxaline as promising scaffold for G-quadruplex DNA targeting
    Asmae Zanzoul
    Youssef Ramli
    El Mokhtar Essassi
    Geneviève Pratviel
    Medicinal Chemistry Research, 2014, 23 : 4042 - 4049
  • [4] A benzimidazopyridoquinoxaline as promising scaffold for G-quadruplex DNA targeting
    Zanzoul, Asmae
    Ramli, Youssef
    Essassi, El Mokhtar
    Pratviel, Genevieve
    MEDICINAL CHEMISTRY RESEARCH, 2014, 23 (09) : 4042 - 4049
  • [5] Duplex formation in a G-quadruplex bulge
    Thi Quynh Ngoc Nguyen
    Lim, Kah Wai
    Anh Tuan Phan
    NUCLEIC ACIDS RESEARCH, 2020, 48 (18) : 10567 - 10575
  • [6] Computational Prediction of G-Quadruplex Formation
    Calvert, Jacob S.
    Kreig, Alex
    Sinha, Saurabh
    Myong, Sua
    BIOPHYSICAL JOURNAL, 2015, 108 (02) : 13A - 13A
  • [7] Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition
    Waller, Zoe A. E.
    Shirude, Pravin S.
    Rodriguez, Raphael
    Balasubramanian, Shankar
    CHEMICAL COMMUNICATIONS, 2008, (12) : 1467 - 1469
  • [8] Erratum to: A benzimidazopyridoquinoxaline as promising scaffold for G-quadruplex DNA targeting
    Asmae Zanzoul
    Youssef Ramli
    El Mokhtar Essassi
    Geneviève Pratviel
    Medicinal Chemistry Research, 2015, 24 : 3127 - 3127
  • [9] How to split a G-quadruplex for DNA detection: new insight into the formation of DNA split G-quadruplex
    Zhu, Jinbo
    Zhang, Libing
    Dong, Shaojun
    Wang, Erkang
    CHEMICAL SCIENCE, 2015, 6 (08) : 4822 - 4827
  • [10] A New Pathway of DNA G-Quadruplex Formation
    Ceru, Slavko
    Sket, Primoz
    Prislan, Iztok
    Lah, Jurij
    Plavec, Janez
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (19) : 4881 - 4884
12345