Pyroptosis-Inducing Biomaterials Pave the Way for Transformative Antitumor Immunotherapy

被引：0
|
作者：
Yin, Hao [1 ,4 ,5 ]
Chen, Tanzhou [3 ]
Hu, Xiaoqu [3 ]
Zhu, Wenting [2 ]
Li, Yida [4 ,5 ]
Sun, Wenjie [4 ,5 ]
Li, Lei [6 ]
Zhang, Hongmei [2 ]
Wang, Qinyang [1 ,3 ,4 ,5 ,6 ]
机构：
[1] Wenzhou Med Univ, Inst Adv Res, Wenzhou 325027, Zhejiang, Peoples R China
[2] Air Force Mil Med Univ, Xijing Hosp, Dept Oncol, Xian 710032, Shaanxi, Peoples R China
[3] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou 325027, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Zhejiang Engn Res Ctr Innovat & Applicat Intellige, Wenzhou Key Lab Basic Sci & Translat Res Radiat On, Dept Radiat & Med Oncol,Affiliated Hosp 2, Wenzhou 325027, Zhejiang, Peoples R China
[5] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China
[6] Xi An Jiao Tong Univ, Hosp 1, Xian 710061, Shanxi, Peoples R China
来源：
ADVANCED SCIENCE | 2024年
基金：
中国国家自然科学基金;
关键词：
antitumor immunotherapy; biomaterials; gasdermin; pyroptosis; GASDERMIN D; PHOTODYNAMIC THERAPY; MEDIATED PYROPTOSIS; TUMOR PYROPTOSIS; PROTEIN FAMILY; APOPTOSIS; EXPRESSION; GSDMD; LOCALIZATION; ACTIVATION;
D O I：
10.1002/advs.202410336
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Pyroptosis can effectively overcome immunosuppression and reactivate antitumor immunity. However, pyroptosis initiation is challenging. First, the underlying biological mechanisms of pyroptosis are complex, and a variety of gasdermin family proteins can be targeted to induce pyroptosis. Second, other intracellular death pathways may also interfere with pyroptosis. The rationally designed gasdermin protein-targeting biomaterials are capable of inducing pyroptosis and have the capacity to stimulate antitumor immune function in a safe and effective manner. This review provides a comprehensive overview of the design, function, and antitumor efficacy of pyroptosis-inducing materials and the associated challenges, with a particular focus on the design options for pyroptosis-inducing biomaterials based on the activation of different gasdermin proteins. This review offers a valuable foundation for the further development of pyroptosis-inducing biomaterials for clinical applications.
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页数：29
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