Effect of O6-methylguanine on the stability of G-quadruplex DNA

被引：0
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作者：
Mekmaysy, Chongkham S. [1 ]
Petraccone, Luigi [1 ,2 ]
Garbett, Nichola C. [1 ]
Ragazzon, Patricia A. [1 ]
Gray, Robert [1 ]
Trent, John O. [1 ]
Chaires, Jonathan B. [1 ]
机构：
[1] James Graham Brown Cancer Center, University of Louisville, 529 South Jackson Street, Louisville, KY 40202, United States
[2] Department of Chemistry P.Corradini, University of Naples Federico II, via Cintia, 4, I-80126 Napoli, Italy
来源：
Journal of the American Chemical Society | 2008年 / 130卷 / 21期
关键词：
The effects of substitution of O6-methylguanine on the structure and stability of a human telomere quadruplex was studied by circular dichroism; thermal denaturation; analytical ultracentrifugation; and molecular dynamics simulations. The results show that; while quadruplex structures can form containing the modified base; they are much less stable than the normal unmodified structure. The extent of destabilization is critically dependent on the exact position of the modified base within the quadruplex structure. Copyright © 2008 American Chemical Society;
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页码：6710 / 6711
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