Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration

被引：0
|
作者：
Wu, Yuhao [1 ,2 ]
Shen, Shiwei [1 ,2 ]
Shi, Yifeng [1 ,2 ,3 ]
Tian, Naifeng [1 ,2 ,3 ]
Zhou, Yifei [1 ,2 ,3 ]
Zhang, Xiaolei [1 ,2 ,3 ,4 ]
机构：
[1] Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China
[2] The Second School of Medicine, Wenzhou Medical University, Wenzhou, China
[3] Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, China
[4] Chinese Orthopaedic Regenerative Medicine Society, Hangzhou, China
来源：
Frontiers in Bioengineering and Biotechnology | 2022年 / 10卷
基金：
中国国家自然科学基金;
关键词：
Cytology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP) produced by senescent cells is found to remodel extracellular matrix (ECM) metabolism and destruct homeostasis. Elimination of senescent cells by senolytics and suppression of SASP production by senomorphics/senostatics are effective strategies to alleviate degenerative diseases including IVDD. Here, we review the involvement of senescence in the process of IVDD; we also discuss the potential of senolytics on eliminating senescent disc cells and alleviating IVDD; finally, we provide a table listing senolytic drugs and small molecules, aiming to propose potential drugs for IVDD therapy in the future. Copyright © 2022 Wu, Shen, Shi, Tian, Zhou and Zhang.
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