Fmoc-amino acid-based hydrogel vehicle for delivery of amygdalin to perform neuroprotection

被引：0
|
作者：
Yang Z.-Y. [1 ]
Zhong Y.-Y. [2 ]
Zheng J. [3 ]
Liu Y. [3 ]
Li T. [1 ]
Hu E. [1 ]
Zhu X.-F. [1 ]
Ding R.-Q. [1 ]
Wu Y. [1 ]
Zhang Y. [3 ]
Tang T. [1 ]
He F. [4 ]
Wang S.-S. [5 ]
Wang Y. [1 ]
机构：
[1] Institute of Integrative Medicine, Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha
[2] Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai
[3] Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety, College of Chemistry and Chemical Engineering, Central South University, Changsha
[4] Department of General Surgery, Xiangya Hospital Central South University, Changsha
[5] Postpartum Health Care Department, Hunan Provincial Maternal and Child Health Care Hospital, Changsha
来源：
Smart Materials in Medicine | 2021年 / 2卷
基金：
中国国家自然科学基金;
关键词：
Amygdalin; Complex hydrogel; Fmoc-Tyr-OH anti-Inflammation; Neural regeneration; Self-assembly;
D O I：
10.1016/j.smaim.2020.10.004
中图分类号：
学科分类号：
摘要：
Amygdalin is widely distributed in the plant kingdom. Oral delivery of amygdalin releases hydrogen cyanide upon endogenous enzymes causing potential toxic effects to humans. Here, we fabricate Fmoc-Tyr–OH–amygdalin hydrogel (FTOA) which represents L-tyrosine derived low molecular weight hydrogelator entrapping amygdalin. Fourier Transform Infrared Spectroscopy and the Fluorescent Emission Spectrum elucidated the complexation process between the amygdalin and Fmoc-Tyr-OH (FTO). Amygdalin was sustainably released from FTOA at different pH buffer. The rheological behavior similar to the brain supported that the hydrogel tended to be a preferable neural scaffold. Moreover, animal studies showed FTOA significantly promoted neural-functional recovery. This hydrogel achieved a great decrease in damage volume according to H&E staining. Additionally, we found that FTOA enhanced tissue recovery. Simultaneously, the released amygdalin gave a markedly neural inflammatory suppression. Taken together, this study highlights that Fmoc-based gelator encapsulate amygdalin forming a stable hydrogel to perform sustained-release and improve efficacy with minimal side effects. © 2021
引用
收藏
页码：56 / 64
页数：8
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