Punicalagin Alleviates Aged Bronchial Asthma by Inhibiting Th2 Differentiation through IL-4/STAT6 and Jagged1/Notch Pathways

被引：1
|
作者：
Yu, Li [1 ]
Li, Jianying [1 ]
机构：
[1] The Division of General Medicine, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Zhuang Autonomous Region, Nanning,530021, China
来源：
Journal of Healthcare Engineering | 2022年 / 2022卷
关键词：
Compilation and indexing terms; Copyright 2025 Elsevier Inc;
D O I：
1184677
中图分类号：
学科分类号：
摘要：
Blood - Diseases - Patient treatment
引用
收藏
相关论文
共 50 条
  • [21] Modulation of cytokine expression and STAT-6 activation in human TH1 and TH2 cells by IL-4 and IL-12
    Kinzel, B
    Kristofic, C
    Moriggl, R
    Brinkmann, V
    10TH INTERNATIONAL CONGRESS ON IMMUNOLOGY, VOLS 1 AND 2, 1998, : 421 - 425
  • [22] IL-27 overexpression alleviates inflammatory response in allergic asthma by inhibiting Th9 differentiation and regulating Th1/Th2 balance
    Xiong, Peng
    Liu, Tonglin
    Huang, Hao
    Yuan, Yi
    Zhang, Wendi
    Fu, Lina
    Chen, Yu
    IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2022, 44 (05) : 712 - 718
  • [23] IL-4 and IL-13 Promote Proliferation of Mammary Epithelial Cells through STAT6 and IRS-1
    Wu, Wan-Ju
    Wang, Sue-Hong
    Wu, Chun-Chi
    Su, Yi-An
    Chiang, Chin-Yin
    Lai, Ching-Hong
    Wang, Tsung-Hsiang
    Cheng, Tsung-Lin
    Kuo, Jia-Yu
    Hsu, Tsai-Ching
    Lin, Ting-Hui
    Lee, Yi-Ju
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (21)
  • [24] Cutting edge: Differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4
    Zhang, SM
    Lukacs, NW
    Lawless, VA
    Kunkel, SL
    Kaplan, MH
    JOURNAL OF IMMUNOLOGY, 2000, 165 (01): : 10 - 14
  • [25] Pyrroloquinolinequinone Alleviates Airway Inflammation via Down-Regulation IL-4/STAT6 Pathway in Ovalbumin-Induced Murine Asthma Model
    Min, Z.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
  • [26] Coriolus versicolor Suppresses Inflammatory Bowel Disease by Inhibiting the Expression of STAT1 and STAT6 Associated with IFN-γ and IL-4 Expression
    Lim, Beong Ou
    PHYTOTHERAPY RESEARCH, 2011, 25 (08) : 1257 - 1261
  • [27] Th2 cell-derived IL-4/IL-13 promote ILC2 accumulation in the lung by ILC2-intrinsic STAT6 signaling in mice
    Symowski, Cornelia
    Voehringer, David
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 (09) : 1421 - 1432
  • [28] IL-4 induces Th2 cells to resist the IL-27 counterregulation by downregulating STAT1 and STAT2 phosphorylation
    Chen, Zhihong
    Wang, Shanze
    Bai, Chunxue
    Alam, Rafeul
    Huang, Hua
    EUROPEAN RESPIRATORY JOURNAL, 2012, 40
  • [29] Differential expression of chemokines in T helper type 1 (Th1) and Th2 cells is dependent on Stat6 but not Stat4
    Zhang, SM
    Lukacs, NW
    Lawless, VA
    Kunkel, SL
    Kaplan, MH
    FASEB JOURNAL, 2000, 14 (06): : A1092 - A1092
  • [30] Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile
    Jankovic, D
    Kullberg, MC
    Noben-Trauth, N
    Caspar, P
    Paul, WE
    Sher, A
    JOURNAL OF IMMUNOLOGY, 2000, 164 (06): : 3047 - 3055
12345