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The effect of unsteady flow rate increase on in vitro mouth-throat deposition of inhaled boluses

被引：0
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作者：
Grgic, B. [1 ]
Martin, A.R. [1 ]
Finlay, W.H. [1 ]
机构：
[1] Aerosol Research Laboratory of Alberta, Department of Mechanical Engineering, University of Alberta, Edmonton, T6G 2G8, Canada
来源：
Journal of Aerosol Science | 2006年 / 37卷 / 10期
关键词：
A procedure for measuring the effects of flow increase rate (FIR) on mouth-throat and downstream filter (lung) deposition was developed. A respiratory aerosol probe (RAP) was used for generation and delivery of small aerosol boluses. This device employs computer controlled; fast opening and closing valves; which allow aerosol injection at a predetermined time during inhalation. Flow was driven by a pulmonary waveform generator (PWG) breathing machine. Monodisperse; 5 μ m diameter dioctylphthalate (DOP) particles were used. The following experimental flow conditions were tested: bolus injection into a steady-state flow of 30 l/min; and bolus injection into unsteady flow accelerating through 30 l/min at either 2 or 4 l / s2. In addition; numerical simulation of the effects of FIR on mouth-throat deposition of aerosol boluses was performed. Our results show that unsteady flow resulted in enhanced mouth-throat deposition. This difference can be explained by the higher velocity reached by the particles at their primary deposition site within the mouth-throat due to the accelerating flow rate (which reaches approximately 40 l/min by the time the particles deposit in the area of the larynx). This hypothesis is supported by data with bolus injection into a steady flow rate of 40 l/min; which yields mouth-throat deposition that does not differ significantly from the unsteady case. © 2006 Elsevier Ltd. All rights reserved;
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页码：1222 / 1233
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