The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links

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Rahman, Khondaker M. [1 ]
Thompson, Andrew S. [2 ]
James, Colin H. [1 ]
Narayanaswamy, Mathangi [1 ,3 ]
Thurston, David E. [1 ,3 ]
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[1] Gene Targeted Drug Design Research Group, School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, United Kingdom
[2] Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, United Kingdom
[3] Spirogen Ltd., School of Pharmacy, University of London, WC1N 1AX, United Kingdom
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页码:13756 / 13766
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