Synthesis, characterization, and antimicrobial activity of kojic acid grafted chitosan oligosaccharide

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[1] Liu, Xiaoli
[2] Xia, Wenshui
[3] Jiang, Qixing
[4] Xu, Yanshun
[5] Yu, Peipei
来源：
Xia, W. (xiaws@jiangnan.edu.cn) | 1600年 / American Chemical Society卷 / 62期
关键词：
A novel water-soluble chitosan oligosaccharide (COS) derivative; chitosan oligosaccharide/kojic acid grafts assigned as COS/KA; was prepared by using the selective partial alkylation of N-benzylidene COS and chlorokojic acid in the presence of dimethyl sulfoxide (DMSO) and pyridine (Py). The derivative was characterized by UV-vis spectroscopy; FTIR; 1H NMR; TGA; SEM; and XRD techniques; which showed that the alkylation reaction took place at the C-6 and C-3 positions of COS. The results showed that the degree of substitution (DS) for COS/KA was from 0.38 to 1.21; and the product exhibited an excellent solubility in organic solvents and distilled water. The antibacterial results indicated that the antibacterial activity of COS/KA was strengthened relative to COS with the increase of DS for Staphylococcus aureus; Escherichia coli; Aspergillus niger and Saccharomyces cerevisiae. These findings provide important supports for developing new antibacterial agents and expand the scope of application of COS in the food industry. © 2013 American Chemical Society;
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